Lilly Research Scientist - Biomaterials, Bio-Conjugation, and Drug Delivery in Indianapolis, Indiana

34492BR

Title Research Scientist - Biomaterials, Bio-Conjugation, and Drug Delivery

City Indianapolis

State / Province Indiana

Country USA

Workplace Arrangement Local

Company Overview At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Responsibilities The Biotechnology Discovery Research (BioTDR) organization at Lilly is responsible for discovering and optimizing novel biotherapeutics (peptides, proteins, antibodies) for advancement into the clinic in key areas of unmet medical need including diabetes, immunology, oncology, neuroscience, and others.

One of the focus areas of the Formulation & Delivery Team (FDT) in BioTDR is to establish physicochemical characterization tools, analytical capabilities, cell-based assays, formulation platforms, and drug delivery strategies to support innovative approaches that enable oral absorption of peptides. This is a cross-functional effort with both discovery and development groups including protein engineering, therapeutic area biology, ADME, chemistry, and small drug and bioproduct development teams to ensure that candidate molecules have the characteristics that ensure successful translation from discovery to the clinic.

We are currently looking for a talented, highly-motivated, and technically competent Biomaterials, Bio-Conjugation, and Drug Delivery Scientist to become part of our team. You must have a strong foundation in organic chemistry, polymer chemistry, materials science/engineering with a record of achieving technology development and research goals on aggressive timelines through effective cross-functional collaboration. You should have significant experience in polymer synthesis using controlled polymerization techniques (e.g. RAFT, ATRP), development of nano-carriers (e.g. hydrogels, particles, micelles, dendrimers), conjugation of small molecules, peptides, proteins, antibodies to polymeric carriers using versatile synthetic approaches, and analytical characterization of complex nano-delivery products. Prior experience in formulation and process development at different scales (Bench to pilot scale) for biologics is highly desirable.

Responsibilities

  • Independently contribute with minimal supervision from the bench (design and execution of studies, critical analysis of data, presentation of results) to multiple research projects and provide critical data to inform decisions in a cross-functional team.

  • As a member of a cross-functional project team, collaborate with partners from peptide chemistry, biology, ADME, and development team to define drug delivery strategies and provide stage-appropriate formulations for preclinical studies.

  • Keep abreast of new technologies/capabilities relevant to this role and strive to implement them to push research projects forward.

  • Author data summaries, technical reports, standard operating procedures, publications, and presentations.

Basic Qualifications

  • A PhD in Chemistry, Chemical/Biomedical Engineering, Material Sciences, or other related field

Additional Skills/Preferences

  • Previous experience in monomer, polymer, and nanomaterial synthesis, polymer characterization (GPC, NMR, HPLC, TGA, and DSC), nano-carrier formulations with strong technical proficiency of analytical instrumentation (DLS and HPLC) are required

  • Applicant should be bright, organized, self-motivated and capable of working independently, and in a collaborative multi-disciplinary environment.

  • A solid research record demonstrated by patents, publications, or presentations preferably in the area of targeted drug delivery, formulation of peptides, and oral bioavailability.

  • Excellent oral and written communication skills and experience with data management software

  • Interest and ability to work in a dynamic, fast-paced environment, and be capable of handling multiple tasks while meeting timelines

  • Understanding of peptide chemistry, structure, conformation, physicochemical properties, and how this information influence formulation approaches for oral delivery is highly desirable

  • Ability to lead projects and work productively in an interdisciplinary team environment

  • Flexibility to adjust priorities over time to meet organizational and scientific goals

  • Some experience with supervision of direct reports

Additional Information

  • Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Removal Date 09-Nov-2017