Lilly Research Scientist-PBPK Modeler in Indianapolis, Indiana
Title Research Scientist-PBPK Modeler
State / Province Indiana
Company Overview At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
Responsibilities The Mechanistic Pharmacokinetics group within The Department of Drug Disposition (ADME) is searching for a PBPK modeler. The Department of Drug Disposition is a multidisciplinary group, utilizing in vitro, in vivo, and in silico approaches to study the pharmacokinetics, absorption, and disposition of new chemical entities. The scientist will function as a PBPK modeler, part of a team responsible for providing innovative mechanistic PK models to drive and influence decision making on drug Discovery and Development project teams.
Evaluate and apply innovative PBPK/MPK approaches to translate and predict human PK.
Use modeling as a tool to help generate hypotheses, design better studies, inform clinical plans and support registration.
Peer review modeling work from colleagues as appropriate, ensuring high quality standards.
Provide expert modeling consultancy, training and support to others within ADME and within the larger R&D organization
Liaise with ADME, PK/PD and Clinical Pharmacology representatives to communicate the assumptions, limitations, meaning and impact of mechanistic PK models.
Promote and increase the reputation of mechanistic modeling approaches both internally within R&D and externally including regulatory agencies
Provide training and coaching to scientists within the department to increase mechanistic thinking and the application and impact of mechanistic modelling.
Build a strong external network in the field of mechanistic modeling (e.g. academia, consortia) and keep up to date with emerging literature and science in the area
Ph.D. in PBPK modeling, Pharmacokinetics or a related field or
MS and 7 years orBS and 10 years or ofapplicable experience in PBPK, Pharmacokinetics modeling or related field
Hands-on experience in modeling software like SimCYP, GastroPlus, MatLab/Simbiology, NONMEM etc. is required.
Must have a thorough understanding of pharmacokinetics, ADME and PBPK modeling and ability to communicate theory and concepts clearly
Understanding of the implications of PBPK modeling and drug-drug interaction simulations for drug labelling and the international regulatory guidance pertaining to those activities
Collaborative behaviors to build and maintain relationships with R&D customers and the wider modeling community.
Ability to influence, negotiate and communicate with both internal and external stake holders
Limited travel required for conferences, external reviews, and regulatory meetings.
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Removal Date 17-Aug-2017