Lilly Principal/Research Scientist - Medicinal Chemistry in Alcobendas, Spain
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
If you are interested in being considered for employment with a top Pharmaceutical company, please review the following opportunity:
Keep safety as your top priority at any time, striving to maintain a strong safety culture.
Lead small molecule drug discovery chemistry teams through all stages of drug discovery. Contribute to the definition and execution of the scientific strategy for research programs. Coordinate the work of internal colleagues and external collaborators across various disciplines and geographies.
Formulate hypothesis, design and synthetize novel small molecules to engage disease modifying targets and contribute decisively to the advancement of drug discovery programs from early lead generation to submission of candidate drugs to the clinic.
Leverage world-class structure-based drug design technologies and partner with expert colleagues in computational chemistry and biophysics to characterize protein-ligand interactions and gain key insights supporting de-novo molecular design.
Optimize lead compounds to improve potency, selectivity, physicochemical properties and DMPK to meet the desired target product profiles required to invent high-quality medicines.
Deliver laboratory synthetic productivity to inform fast-paced SAR iterations through proposal and execution of synthetic routes.
Team up with colleagues specialized in high-throughput automated synthesis, route optimization and scale-up to maximize the overall efficiency and productivity of the group.
Reach out across disciplines to interact and collaborate with scientists in areas like pharmacology, translational science, ADME and toxicology to address specific program needs, increase your overall business acumen and provide them with Medicinal Chemistry perspectives.
Lead, mentor and develop colleagues to promote personal growth and create new scientific capabilities.
Required Education and Experience:
PhD in Organic or Medicinal Chemistry with >5 years post-graduation medicinal chemistry or small molecule organic synthesis experience in pharmaceutical, biotechnology or academic environments, or MS in Organic or Medicinal Chemistry with >10 years’ experience.
Strong knowledge of the following areas of Small Molecule Drug Discovery:
Structure-based drug design.
Lead optimization to improve potency, selectivity and properties of compounds.
Drug metabolism and pharmacokinetics problem solving.
Computational chemistry tools and methods.
Biophysical techniques such as X-ray crystallography.
Strong Synthetic Organic Chemistry skills with deep and extensive working knowledge of modern synthetic chemistry methodologies, experimental work, isolation/purification techniques and structural analysis of synthetic organic molecules.
Robust track record of scientific contributions including peer reviewed publications, patents and presentations.
Excellent English language oral and written communication skills, ability to engage highly effectively as team player in a multidisciplinary and international environment.
Strong work ethic. Scientific curiosity. Can do, will do attitude.
Experience with chemistry platforms and methodologies used in the discovery and development of novel Targeted Protein Degraders will be highly valued.
Command of scientific informatics and data visualization tools and techniques to undertake computationally driven work such as de-novo design or multi-property optimization will be advantageous.
Knowledge of High Throughput Experimentation techniques applied to parallel synthesis and reaction screening.
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