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Lilly Oligonucleotide Bioanalytical Chemist in Cambridge, Massachusetts

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Organization Overview:

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism

At the Lilly Innovation Center in Cambridge, Massachusetts, we explore how next generation therapeutics, new technologies, data analytics and new care models can improve patient health and the healthcare system. Our Genetic Medicine team in Cambridge shares a passion for challenging conventional wisdom and creating an environment that embraces creative, break-through concepts. The Center offers a start-up environment with large company support. It is located in the heart of Massachusetts’ exploding science and technology cluster and is within walking distance of some of the best academic and industry innovators in the world.

The successful candidate will have a strong research track record in bioanalytical chemistry and be analytically minded, systematic, and embrace data-driven decision making. The scientist will collaborate with multidisciplinary teams across key Lilly therapeutic areas (e.g. neuroscience, diabetes, immunology) to perform experiments to aid development of RNA oligonucleotide drug candidates for the next generation of RNA therapies.

Key responsibilities include:

  • Evaluate oligonucleotide PK and metabolism in cells, tissues, and biofluids, using standard oligonucleotide analytical methods (SL-qPCR, PNA fluorescence hybridization, or LC-MS)

  • Author, develop, and troubleshoot SOPs for bioanalytical assays

  • Use oligonucleotide DMPK data to drive key decision making and prioritization in novel targeted delivery innovation

  • Visualize, summarize, and present results to team members,

  • Identify and drive solutions toward innovation in the RNA Therapeutics area,

  • Demonstrate high learning agility regarding grasping and exploiting new scientific concepts and methods across multiple teams,

  • Partner with and support cross-functional partners to drive high-speed innovation,

  • Embrace diversity of thought, background and experience to deliver innovative solutions,

  • Possess strong communication (oral, written), organizational, and leadership skills.

Basic Qualifications:

  • BSc and/or MS Degree in analytical chemistry, biochemistry, or related field with with 2-5+ years of practical experience preferably in industry

Additional Skills/Preferences :

  • The ideal candidate will have hands on experience with HPLC and/or mass spectrometric methods, familiarity with Waters and Agilent HPLC hardware and software

  • Experience with oligonucleotide assay strongly preferred

  • Solid understanding of RNA biology and RNA therapeutics

  • Excellent communication, interpersonal skills, and team-player mindset

  • Demonstrated initiative and appropriate risk-taking

  • Demonstrated technical proficiency

  • High level of organization and attention to detail

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company. If you would like to request an accommodation for medical or religious reasons, you may do so at

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).