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Lilly Post Doctoral Scientist - Drug Product Development, Bioproduct Research & Development (FDE) in Cambridge, Massachusetts

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Due to a strategic commitment to the growth of biotherapeutics within the Lilly portfolio, multiple opportunities are currently available within the Bioproduct Research and Development (BRD) organization. This group is a multidisciplinary organization, focused on the development and commercialization of parenteral formulations of small molecules and large molecules such as monoclonal antibodies, insulin formulations, novel therapeutic proteins, oligonucleotides, and peptides. The organization also has a unique focus on patient centered drug product and delivery system solutions utilizing both internal and external technologies. The Cambridge, MA Lilly site is dedicated to bringing in innovative solutions to drug product development and delivery challenges!

The post-doctoral scientist will be responsible for evaluating new formulation and device strategies for optimizing subcutaneous drug delivery. The candidate will be conducting studies to build the understanding needed to optimize the development of subcutaneous oligo, protein, and peptide drug formulations and delivery systems. The candidate will apply expertise in various aspects of drug delivery to understand the impact of molecule, formulation, and device systems on drug absorption to enable development of innovative drug products and establish novel assays (ex vivo, in vitro, in silico, or in vivo) to evaluate the extent of subcutaneous absorption.

Position Responsibilities:

  • Develop imaging techniques that can help the understanding of subcutaneous behavior of biologics in subcutaneous space.

  • Develop and execute experiments to understand the behavior ofSubQformulationswhen delivered in the subcutaneous space.

  • Develop PK/ PBPKmodelsto predict in vivo subcutaneous absorption

  • Participate in the development of in-vitro, in-vivo methods to assess immunogenicity, transport in subcutaneous tissue

  • Evaluateand developformulation enabling technologies to enhance the bioavailability of biotherapeutics

  • Keep abreast of relevant new technologies / capabilities and regulatory initiatives / requirements.

  • Authoring of technical reports , research grants, journal publications and regulatory documents

Minimum Qualifications:

  • PhD in Biomedical Engineering, Pharmaceutical Sciences, Biology or Biochemistry

  • Experience/ knowledge of peptides, proteins or oligonucleotide formulation

Additional skills :

  • Familiarity with subcutaneous physiology

  • PK/ PBPK modeling experience either using commercial software (Gastroplus/SimCYP,PKSim) or developing custom codes

  • Familiarity with drug delivery technologies such as Lipid nanoparticles

Additional Information:

  • This position is not permanent. It is for a fixed duration of two years with potential to extend to 3 years and for maximum of up to 4 years.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company. If you would like to request an accommodation for medical or religious reasons, you may do so at

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!