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Lilly Post-Doctoral Scientist- Formulation Development (FDE) in Cambridge, Massachusetts

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At the Lilly Innovation Center in Cambridge, Massachusetts, we explore how next generation therapeutics, new technologies, data analytics and new care models can improve patient health and the healthcare system. Our team in Cambridge shares a real passion for challenging conventional wisdom and creating an environment that embraces creative, break-through concepts. The Center offers a start-up environment with large company support. It is located in the heart of Massachusetts’ exploding science and technology cluster and is within walking distance of some of the best academic and industry innovators in the world.

Organization Overview:

The Bioproduct Research and Development (BR&D) organization strives to deliver creative medicines to patients through the development and commercialization of insulins, oligonucleotides, monoclonal antibodies, novel therapeutic proteins, and peptides. This organization is a multidisciplinary group that works collaboratively with our discovery and manufacturing colleagues. Located in Indianapolis, IN and Cambridge MA, scientists have full access to our scientific excellence and engineering capabilities.

Do you wish for a role working with top scientists using groundbreaking, state of the art technology? Are you looking to grow your career as a Formulations and Drug Delivery Scientist for therapies like RNA and gene delivery? If your answer is yes, then this could be the right role for you!

As a Postdoctoral Scientist -Formulation Development, the scientist will be exposed to full breadth of opportunities to develop and enable novel formulations and delivery options for oligonucleotides and/or gene delivery including Adeno-Associated Viral Vector mediated gene delivery. Therefore, the candidate must demonstrate a history of strong technical depth, scientific leadership and a willingness to promote a collaborative, team-based approach to problem solving.

Responsibilities:

The scientist is responsible for designing and conducting research to adavnce our efforts in oligonucleotide research and gene delivery. The scientist is also responsible for working collaboratively with a wide array of scientists and engineers from many disciplines, leading/supporting relevant research initiatives, bringing new capabilities / technologies and providing internal/external influence.

The Responsibilities For This Role Will Include

  • Develop nanoparticle formulations for nucleic acid therapeutics and assess what formulation parameters are needed to optimize lead formulations

  • Formulate RNAs for in vitro and in vivo animal studies

  • Work with the analytical team to transfer and test analytical methods to characterize formulations

  • Work closely across functions to understand portfolio needs in an interdisciplinary fast paced environment

  • Deliver results under tight deadlines

  • Work with vendors and CROs

  • Maintain thorough electronic lab notebooks and documentation records

  • Adhere to all laboratory safety requirements and procedures, assist in managing lab activities including lab equipment maintenance and the ordering and receiving/shipping of lab supplies

  • Create and write analytical reports and SOPs to support development

  • Design and execute experiments to explore the impact of excipients on formulation stability and to understand physical and chemical stability of oligonucleotides

  • Keep abreast of relevant new technologies / capabilities

  • Authoring of technical reports and regulatory documents

  • Present and publish research results internally and externally

  • Mentor less experienced scientists and engineers to deliver the portfolio and innovation projects.

Basic Qualifications

  • Ph.D. in Chemical ngineering, Pharmaceutical Sciences, Pharmaceutical Chemistry, Biomedical Engineering, Biology, Chemistry or a related field.

Additional Skills/Preferences

  • 0-5 years of prior experience in oligonucleotides and/or Gene Delivery development programs.

  • Familiarity with development of formulation of adeno-associated viral vector products is a plus.

  • Apply engineering fundamentals towards designing and optimizing drug delivery platforms which may include RNA, LNPs, PnPs and PmPs.

  • Understanding gene and cell therapies and serve as a member of integrated team responsible for the discovery and development them therapies

  • Expertise in formulation, process development and optimization

  • Ability to work in the lab independently

  • Strong communication skills and ability to work effectively in a highly collaborative research environment beyond BRD and Lilly, including external academic researchers and industry collaborations.

Additional Information:

  • This position is not permanent. It is for a fixed term with a maximum time of 4 years.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company. If you would like to request an accommodation for medical or religious reasons, you may do so at workplace_adjustment@lilly.com.

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!

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