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Lilly Principal Research Scientist-Data Sciences in Cambridge, Massachusetts

Job Category:


Type of Employment:

Full-Time Employment - FTE


Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Our Neuroscience Next Generation Therapeutics team is an innovation-focused organization striving to identify, develop and apply the most cutting-edge technologies to deliver maximum benefit to our patients. Are you looking to be part of a growing, driven team where you will help to progress new therapeutic approaches toward clinical development and commercialization? Oligonucleotide-based therapies and other novel modalities represent an existing avenue of research toward development of the next generation of therapies.

The Next Generation Therapeutics group is a newly formed team with a focus on using novel therapeutic modalities to deliver medicines for chronic pain and neuro degenerative disorders. The group, based at our Cambridge Innovation Center in Kendall Square, will work with internal and external partners to identify and deliver new novel therapies into patients at speed. The team is seeking experienced and inspiring scientists to join our fast-paced, interdisciplinary team as we leverage innovative RNA/oligonucleotide/gene and genomic based therapeutic modalities to enhance our portfolio.

Key Objectives/Deliverables:

  • Utilize internal and external -omics datasets to deliver novel insights into the biology of disease, validate new targets and improve selection of patients for clinical trials

  • Identify clinically relevant disease and response loci for novel therapeutics from -omics datasets

  • Perform statistical analyses and modelling in collaboration with statisticians to evaluate efficacy, PK and PD of novel treatments

  • Assess the scientific and technical integrity of algorithms and statistical techniques used within the analysis pipeline

  • Develop data pipelines for the rapid automation and analysis of study data

  • Create data structures for the storage, integration and secondary analysis of data

  • Prevent analysis bottlenecks by utilizing high performance computing capabilities

  • Deliver software solutions: image analysis, machine learning and AI

  • Apply machine-learning methods (e.g. deep learning, reinforcement learning, and generative adversarial networks) to biological imaging data to evaluate temporal and spatial effects of novel targets

  • Perform secondary analyses to create additional value from Lilly’s data assets, create high quality data visualizations and present research findings to the scientific community

Basic Qualificiations:

  • PhD degree in computer and information sciences, bioinformatics, cheminformatics, computational biology/chemistry or related field

  • 5 or more years of relevant academic or industry/biotech experience post education

Additional Skills/Preferences:

  • Excellent interpersonal skills and demonstrated efficiency in collaborating cross-functionally

  • Practical experience in pharmaceutical or biotech industry

  • Experience in RNAi discovery, especially in siRNA design

  • Postgraduate school experience in one or more of the following areas: bioinformatics, cheminformatics, computational chemistry and machine-learning

  • Demonstrated experience in processing, organizing, analyzing and visualizing complex data and information from disparate sources and ability to extract insight from data

  • Health and research data literacy with the ability to build and curate databases and knowledge graphs for analysis

  • Expertise in solving scientific problems using programming languages (R/ Python/ C++) and developing visualizations (e.g. JavaScript and Rshiny or Flask platforms)

  • Extensive experience in data extraction and manipulation (e.g. SQL, GraphQL and Cypher)

  • Experience working with Cloud (AWS) and High-Performance Computing environments (e.g. Kubernetes and grid engine)

  • Recruit, coach, mentor and actively grow the Data Sciences team

Additional Information:

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Company Overview:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. #WeAreLilly

Posted Date:


Region: North America

City: Cambridge

State: Massachusetts

Country: USA

Location Details:

Req Id: 54596BR