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Lilly Principal Research Scientist - Peptide/Oligonucleotide Bioconjugation Chemistry in Cambridge, Massachusetts

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Our RNA Therapeutics team is an innovation-focused organization striving to identify, develop and apply the most groundbreaking technologies to deliver maximum benefit to our patients. Our agile and diverse team strives to operate as an autonomous 'biotech-like' company within the walls of Lilly. We seek to impact our communities, families and patients we serve.

In the RNA Team, both basic and applied sciences are vital. We are looking for creative and energetic problem solvers to lead in a multidisciplinary team at the front edge of innovation. Key facets of the role are identifying next generation tissue opportunities, leading teams in design of ligands for specific cellular and tissue delivery and synthesis and, purification for sophisticated molecule assembly. These are efforts that progress our innovative preclinical portfolio with focus on scientific precision and portfolio effectiveness. We are building state-of-the art expertise in major oligonucleotide-based modalities and delivery approaches, with an emphasis on innovative approaches with potential for breakthrough efficacy.

This position will play a lead role, acting as senior scientific advisor and provide key technical knowledge to design and implement scientific research projects to develop oligonucleotide/RNA based therapeutics. You will join our fast-paced, interdisciplinary team as we apply novel RNA/oligonucleotide based therapeutic modalities to enhance the Lilly portfolio. The successful applicant will use their knowledge and technical expertise to complement and enable core capabilities and help drive the revelation and development of RNA-based clinical candidates. Do you have a passion for innovative approaches and modalities in discovery and development focused on identifying impactful therapies for the patient? We want you on our team!

Basic Qualifications:

  • PhD in Organic Chemistry or related field with a minimum of 4 years of proven experience in bioconjugation techniques with peptides or macromolecules.

Additional Skills/Preferences:

  • Provide strategic direction to bioconjugation capabilities for oligonucleotides, propose new insights to team members and collaborators

  • Implement or direct conjugation of targeting ligands such as peptides, small molecule conjugation to oligonucleotides, purification and characterization techniques

  • Demonstrate working knowledge and experience in the areas of bioconjugation techniques to produce novel oligonucleotide conjugates.

  • Build and lead internal team of chemists and handle external CRO workstreams as needed.

  • Confident, execution focused and team oriented with an ability to thrive in an entrepreneurial environment

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company. If you would like to request an accommodation for medical or religious reasons, you may do so at workplace_adjustment@lilly.com.

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!

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