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Lilly Research Scientist - Bioconjugation Chemistry in Cambridge, Massachusetts

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Our RNA Therapeutics team is an innovation-focused organization striving to identify, develop and apply the most groundbreaking technologies to deliver maximum benefit to our patients. Our agile and diverse team strives to operate as an autonomous 'biotech-like' company within the walls of Lilly. We seek to impact our communities, families and patients we serve.

In the RNA Team, both basic and applied sciences are vital. We are looking for creative and energetic problem solvers to lead in a multidisciplinary team at the front edge of innovation. Key facets of the role are identifying next generation tissue opportunities, leading teams in design of ligands for specific cellular and tissue delivery and synthesis and purification for sophisticated molecule assembly that progress an innovative preclinical portfolio with focus on scientific precision and portfolio effectiveness. We are building state-of-the art expertise in major oligonucleotide-based modalities and delivery approaches, with an emphasis on innovative ways with potential for breakthrough efficacy.

You will join our fast-paced, interdisciplinary team as we use novel RNA/oligonucleotide based therapeutic modalities to enhance the Lilly portfolio. The successful applicant will apply their knowledge and technical expertise to complement and enable core capabilities and help drive the revelation and development of RNA-based clinical candidates. Do you have an interest in innovative approaches and modalities in discovery and development focused on identifying impactful therapies for the patient? We want you on our team!

Basic Qualifications:

PhD in Organic Chemistry or related field

Additional Skills/Preferences:

  • Experience in peptides synthesis, purification and their conjugation chemistries.

  • Lead efforts in the areas of targeted delivery of oligonucleotides and contribute to intellectual property by way of patents and publications.

  • Maintains an appreciation of the scientific literature and understanding of the state of the art in ASO and siRNA chemistry, purification, and conjugations strategies.

  • Proficiency with analytical and physiochemical characterization of bioconjugates (ex., mass spectrometry, separation techniques and other biophysical/biochemical techniques)

  • Highly motivated and flexible with ability to work in fast-paced environment. Ability to provide creative solutions to challenging problems. Desire to learn and tackle new challenges and initiatives.

  • Excellent communication skills with a proven track record of scientific excellence as evidenced by strong publication record

  • Confident, execution focused and team oriented with an ability to thrive in an entrepreneurial environment

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

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As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).