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Lilly Research Scientist - In Vivo Neuroscience in Cambridge, Massachusetts

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Our Neuroscience Next Generation Therapeutics team is an innovation-focused organization striving to identify, develop and apply the most cutting-edge technologies to deliver maximum benefit to our patients. You will be part of a growing, driven team working to progress new therapeutic approaches toward clinical development and commercialization. Oligonucleotide-based therapies and other novel modalities represent an existing avenue of research toward development of the next generation of therapies.

The Next Generation Therapeutics group is a newly formed team with a focus on using novel therapeutic modalities to deliver medicines for chronic pain and neurodegenerative disorders. We are based at our Cambridge Innovation Center in Kendall square and work with internal and external partners to identify and deliver novel therapies into patients at speed. We are seeking experienced and inspiring scientists to join our fast-paced, interdisciplinary team as we use innovative RNA/oligonucleotide/gene and genomic based therapeutics to enhance our portfolio.

Key Objectives:

  • Work with project teams to design and plan live-phase experiments to support the preclinical characterization and evaluation of novel therapeutic molecules, and provide scientific expertise in study conduct, design, and interpretation.

  • Work in close collaboration with external CROs to ensure CROs deliver the highest quality science and animal welfare, through in-person interactions.

  • Perform small animal stereotaxic surgeries including but not limited to intracerebral and intracerebroventricular injections in rodents.

  • Perform CNS tissue dissection, trimming and processing, collect bodily fluids (blood, cerebrospinal fluid).

  • Support technology development for improving the delivery of novel therapeutics to regions of interest in the nervous system.

  • Train research associates and provide the necessary support to associates and team leaders to maximize team performance.

  • Provide guidance to less experienced personnel and assist with the development, training, and implementation of new technical procedures.

  • Handle the supply and demand of relevant in vivo models by working directly with suppliers

Do you have experience developing and working with neuroscience-relevant in vivo models and assays to support drug discovery programs? This is the perfect job for you! Come join the Lilly team!

Basic Qualifications:

PhD degree in neuroscience or related fields

Additional Skills/Preferences:

  • Hands-on competencies in designing and executing in vivo pharmacological experiments across neuroscience indications.

  • Expert knowledge of the relevant key literature on in vivo methods and assays.

  • Extensive stereotaxic surgery expertise in rodent models (intracerebroventricular, intracerebral), experience with intrathecal delivery favorable but not required.

  • Experience with intravenous, intraperitoneal and oral route injection/administration.

  • Strong expertise in CNS tissue dissection and processing.

  • Familiarity with standard PK/PD assays.

  • Strong problem solving and time management skills with demonstrated experience working in an exciting, very fast-paced environment.

  • Able to work independently as well as within a flexible collaborative environment.

  • Excellent communication skills both written and oral and demonstrated efficiency in collaborating across functional boundaries.

  • Strong operational skills including outstanding organizational skills and performing multiple tasks simultaneously.

  • Experience in RNAi/gene therapy discovery.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide valid proof of vaccination to the company.

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!