Loxo@Lilly Principal Scientist, Clinical Biomarker Development in Harrisburg, Pennsylvania
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The Principal Scientist, Clinical Biomarker Development will integrate biomarker research and clinical development, and will be accountable for the design, delivery, and execution of biomarker and diagnostics plans in early phase clinical programs. Programs include early proof of concept through registrational studies in a variety of targets. The role involves cross functional collaborations across Biomarker Operations, Clinical Development and Translational Medicine as well as Diagnostic Medical Affairs. Responsibilities encompass strategic planning to optimize the clinical and registrational utility of Biomarker development plans for assigned projects as well as management and career development of biomarker scientists. This person must thrive in a fast-paced, team-oriented environment and be adaptable to rapidly changing priorities.
Roles and Responsibilities of the Position:
Oversee the integration of biomarker and diagnostic development plans in clinical development with the current oncology treatment landscape, registrational and launch needs for the asset and with external competitors
Ensure individual biomarker scientist plans are developed and implemented optimally according to the strategic needs of the assets and are aligned to company positions and guidelines
Create and foster strong strategic partnerships with colleagues that include Biomarker Operations, pre-Clinical Development, Clinical Operations/Development, Dx Regulatory Affairs and Dx Medical Affairs
Apply Biomarker Development strategy to the design and interpretation of clinical trials
Provide strategic input into data analysis, and engage in critical thinking, to deliver key data generation and interpretation essential for decision making as well as public scientific disclosure
Lead integration with functional teams such as discovery, translational medicine, data science, clinical science etc. to ensure timely analysis, interpretation and disclosure of data to support development of our oncology pipeline
Demonstrate substantial and relevant knowledge of scientific and medical literature with genomics and biomarker expertise and its application to strategic drug development and registration
Apply scientific and operational knowledge to identify and analyze problems and information of considerable complexity and implement effective plans and solutions. Collaborate with operational teams to ensure cohesive planning and strategy
Ability to prioritize effectively and meet multiple deadlines successfully with attention to detail, setting high performance standards.
Proactively generate ideas for improvements and take action to solve problems and achieve goals beyond what is required
Required Qualifications and Preferred Background:
PhD required along with 5-7 years of biomarker experience within an academic or industry setting
Strong preferably within laboratory-based cancer research or clinical trials is preferred
Clinical trial expertise along with experience in oncology with drug development highly desirable
The skills required for success in the job include scientific and analytic ability, ability to think strategically and tactically, an interest in applied clinical research, an ability to work effectively in multifunctional teams and excellent organizational and communication skills.
The candidate must demonstrate proven ability to evaluate, interpret and present complex scientific data to both technical and non-technical audiences
Demonstrated ability to work well with other accomplished professionals within and across functions/teams
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
The physical demands of this job are consistent with an office setting.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
This position’s work environment is office/remote based.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email firstname.lastname@example.org for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.