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Lilly Advisor-Oligonucleotide Characterization in Indianapolis, Indiana

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing, and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

The Lilly RNA Therapeutics Team is seeking an independent, self-motivated, and agile scientist with a proven track record of enabling the design, development, and implementation of analytical methodologies for the characterization and analysis of small molecules and oligonucleotides. The successful candidate will have significant experiences in UPLC, LC-MS, CD, UV-vis and fluorescence-based methods and analytical method development. He/she will be able to provide scientific input to cross functional teams from early discovery to early development and explore new analytical techniques for sophisticated modified oligonucleotides and their conjugates.


  • Act as an analytical representative in cross functional teams to support therapeutic oligonucleotides discovery.

  • Development and execution of analytical methods including but not limit to LC, LC-MS, NMR, CD, UV-vis and fluorescence spectroscopy for the development and characterization of oligonucleotides, and their conjugates.

  • Explore, evaluate, and implement novel analytical techniques to overcome analytical challenges in the characterization of therapeutic oligonucleotides.

  • Ability to operate, troubleshoot, and maintain lab instruments such as UPLC, LC-MS, osmometer, nano drop in good operational conditions.

  • Continuous improvement of existing analytical methods/assays as needed.

  • Work in multidisciplinary teams to establish novel nucleotide flow schemes to support our exploration into new chemical space for RNA therapeutics.

  • Ability to learn new technologies fast and exploit effective scientific concepts and methods across multiple areas.

  • Document experiments, data, technical report, and findings electronically in an accessible manner.

  • Present findings, progress, and data proactively and regularly in group and department meetings

  • Provide leadership and mentorship to scientific staff and help group members growth and continued technical and professional development via excellence and knowledge sharing.

  • Possess collaborative mindset with excellent verbal and written communication skills with attention to detail.

Basic Requirements:

  • PhD in Analytical Chemistry, Biochemistry, or Chemistry or other similar scientific area with 0-2+ years of relevant post-graduate experiences

Additional Skills/Preferences:

  • Strong knowledge of nucleic acids chemistry, and oligonucleotide analytical techniques.

  • Expertise in separations science, including but not limited to RP, HILIC, HIC, IEX, SEC and CE.

  • Expertise in mass spectrometry including ESI ionization with a range of mass spectrometer designs (QToF, Orbitrap, QQQ).

  • Experience in UV-vis, CD and fluorescence-based assays for oligonucleotide analysis

  • Prior working experience in bioanalysis is a big plus.

  • Highly self-motivated and self-driven attitude with ability to own and drive projects into success.

  • Strong organizational and communication skills and effective people skills.

  • Capable of continuous learning, open-minded, highly organized, and detail oriented.

  • Ability to balance multiple activities, prioritize and handle ambiguity.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).


At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!