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RESPONSIBILITIES:

This is a technical scientific position in the Peptide Therapeutics Team within Biotechnology Discovery Research in Indianapolis. The individual will have the responsibility to identify, optimize, evaluate, and advance to clinical development of biotherapeutic peptides and conjugates as projects move from concept to clinical development. To accomplish selection and execution of appropriate optimization strategies, the individual will lead and influence projects in the areas of peptide design, SAR, synthesis, conjugation, and characterization. The individual will propose strategies and future directions to meet broader portfolio goals and effectively communicate progress to management and governance committees. Also, will interact cross-functionally within Biotechnology Discovery Research, and across Discovery Chemistry, Genetic Medicines, Therapeutic Area Teams, Drug Disposition, Bioproduct Development and Regulatory Affairs.

KEY OBJECTIVES/DELIVERABLES:

• Lead research efforts that support project teams from concept through optimization with responsibility for identification of candidate therapeutic peptides, material generation and characterization of biopharmaceutical properties using biochemical and biophysical techniques. Implement rational SAR strategies to improve pharmaceutical properties of therapeutic peptide leads and conjugates. This requires a broad repertoire of skills and knowledge including peptide synthesis and conformational analysis, molecular modeling, analytical and physicochemical characterization.

• Therapeutic Area Focus: Is expected to exhibit strong problem-solving abilities and be familiar with understanding and resolving issues that lie at the interface of peptide engineering, pharmaceutical developability and formulation, and biology.

• Leadership: In advancing the optimization of lead therapeutic molecules, will be required to lead/co-lead multidisciplinary teams. Accordingly, strong communication and presentation skills in sharing research findings and team plans, and effective teamwork will be required.

BASIC QUALIFICATIONS:

• A Ph.D. degree in the chemical or biological sciences with a focus on peptide chemistry.

• 0-5 years of experience in a biotechnology/pharmaceutical company, or academia

ADDITIONAL SKILLS AND PREFERENCES:

• Demonstrated leadership in peptide engineering and a track record of advancing biotherapeutics, from concept to clinical development. Experience in multi-molecular conjugation chemistry is preferred.

• Experience using state of the art analytical methods to characterize peptides, proteins and conjugates as demonstrated by publications or patents.

• Demonstrated ability to work cross-functionally, and excellent organizational, communication and presentation skills.

• Appreciation of peptide formulation requirements and experience incorporating pharmaceutical developability assessment in peptide optimization and candidate identification.

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