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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Synthetic Molecule Design and Development (SMDD) organization at Eli Lilly and Company has an exciting opportunity for an innovative synthetic peptide chemist to join our process development organization! You will have the opportunity to join a highly dynamic and cross-functional department pursuing sustainable synthetic peptide development and commercialization. Our peptide group has recently commercialized Mounjaro/Zepbound, which is only one of the many exciting peptides we have in our portfolio, and you will be able to contribute to enabling new sustainable approaches to these synthetic peptides. If you are an innovative peptide chemist and you want to be part of a diverse team of chemical engineers, synthetic chemists, and analytical chemists delivering product and process understanding across a broad range of platforms then this opportunity is for you!

Top candidates for this position will:

• Enable the design, development, and implementation of sustainable, innovative processes for the synthesis of complex peptides.

• Adopt green chemistry and engineering as a means of effecting a paradigm shift to reduce the environmental footprint in the synthetic peptide field: Synthetic Peptide Sustainability Challenges (https://pubs.acs.org/doi/full/10.1021/acs.joc.8b03001) .

• Show proficiency in various modes of peptide synthesis including Solid Phase Peptide Synthesis, Liquid Phase Peptide Synthesis, Semi-Synthesis, and Enzymatic approaches: Mounjaro Hybrid Synthesis (https://pubs.acs.org/doi/abs/10.1021/acs.oprd.1c00108) .

• Have familiarity with chromatography, mass spectrometry, optical spectroscopy, and peptide automation.

• Have strong technical problem-solving ability and have an internal motivation to succeed in team environments.

• Present research findings at conferences and publish in high quality peer-reviewed journals.

Position Responsibilities:

The peptide team is responsible for sustainably enabling the synthesis and commercialization of a variety of synthetically challenging therapeutic peptides. A successful applicant will have experience with peptide synthesis, optimization, and isolation. Primary responsibilities are to:

• Identify ground-breaking peptide technologies as well as trends in sustainable synthetic peptide chemistry, chemical engineering, and continuous manufacturing.

• Identify and exploit new scientific concepts, display strong problem-solving skills, and be self-motivated.

• Engage with Eli Lilly’s Development and Manufacturing organizations to develop a deep understanding of new initiatives and improve existing scientific processes.

• Present research findings at internal forms as well as external conferences.

Basic Qualifications:

• PhD in Chemistry or related field

OR

• MS in Chemistry or related field with 7+ years of relevant experience

Additional Skills/Preferences:

• Proficient in English

• Familiarity with small molecules and synthetic methods

• Familiarity with reversed phase chromatography, ion exchange chromatography, size exclusion chromatography, chiral chromatography

• Hands-on experience with high-resolution mass spectrometry in the characterization of synthetic peptides and experience with MS data interpretation

• Ability to learn and apply technical knowledge to meet changing project needs

• Flexibility and ability to prioritize work to meet interpersonal and scientific goals

• Good interpersonal skills and a sustained tendency for collaborations

Additional Information:

• Travel: 0 to 10%

• Possible exposure to chemicals, allergens, and loud noises

• Position Location: Indianapolis, IN; Lilly Technology Center-North (LTC-N)

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( LillyRecruitingCompliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

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