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Lilly Analytical Chemist in Indianapolis, Indiana

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

We are growing! Lilly is on the forefront of cutting-edge research and has established the Lilly Institute of New Genetics Medicine. The Biotechnology Research/ADME-PK group is looking for scientists interested in pioneering novel drug modalities to join us in this effort. We seek dynamic, energetic, collaborative scientists to work on life-changing therapies for patients involving novel complex molecules including DNA and RNA-based technologies. You will have the opportunity to engage with diverse teams in a ‘biotech-like’ manner within the walls of Lilly where innovative ways of thinking are essential to advance these innovative platforms.

Our ADME team works seamlessly across analytical platforms to address the evolving bioanalytical challenges in discovery research. We seek highly motivated and dedicated scientists to join our fast-paced, interdisciplinary team. The successful applicants will have a working understanding of development and validation of bioanalytical methods and studies performed in an industrial setting. The bioanalytical scientist in this role will interact with various project teams as it relates to ADME activities at Lilly. We look forward to seeing your application and having you on our team!

The bioanalytical team supports all modalities including small molecules, oligonucleotides, peptides and biologics, across analytical platforms (e.g., ligand binding, LC-MS, PCR) and spans both discovery and development projects. Together, we ensure the delivery of the bioanalytical results needed to advance the Lilly portfolio.

Responsibilities

  • Provide internal bioanalytical support for the portfolio including complex method development and troubleshooting.

  • Address innovative bioanalytical challenges.

  • Collaborate cross-functionally with discovery, non-clinical and clinical teams, as appropriate.

  • Interact with internal customers and other partners on bioanalytical issues.

Minimum Qualifications:

  • BS in Bioanalytical Science, Analytical Chemistry, Biochemistry, or related field with at least 1 year of experience performing LC-MS and/or ligand binding assays.

Additional Preferences:

  • LC-MS instrumentation including triple-quadrupole and high resolution mass spectrometry

  • Understanding or experience with LC/MS based sample extraction approaches including protein precipitation, solid-phase extraction, and immunoprecipitation.

  • Understanding or experience with LC/MS based digestion procedures for peptides and proteins.

  • 5 years of relevant experience in industry setting with strong work planning, record keeping, and data analysis skills.

  • Hands-on laboratory experience with large molecule bioanalytical methods/assays including:

  • Experience in large molecule bioanalytical analysis including implementation of new techniques and troubleshooting assays.

  • LC-MS sample analysis workflows for peptide, protein, and oligonucleotide analysis

  • Immunoprecipitation methods

  • Ligand binding platforms such as ELISA, MSD, Gyros, Singulex

  • Immunohistochemistry and in situ hybridization method development

  • Immunoassay/ADA method development

  • Background in/experience with molecular biology techniques such as qRT-PCR

  • Familiarity with related systems and applications (LIMS, regression analysis, basic statistics, pharmacokinetic analysis)

  • Excellent problem-solving skills and initiative

  • Proficient written and spoken English language skills including effective verbal communication

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( LillyRecruitingCompliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

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