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Lilly Post-Doctoral Scientist in Indianapolis, Indiana

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Are you looking to make a significant difference by contributing to our understanding of the contributions of RNA modifying enzymes to the potency and durability of genetic medicines?

We are seeking an ambitious post-doctoral scientist with strong research and communication skills to contribute to highly visible research projects. Your work will contribute to a greater understanding of how RNA modifying enzymes impact the potency and durability of RNA-based genetic medicines, including siRNAs and ASOs as well as CRISPR and RNA editing therapeutics, as well as a greater understanding of clinical translation. In this role, you will:

  • Design, implement and interpret experiments which:

  • Understand the species translation of RNA metabolism in different tissues.

  • Evaluate the impact of RNA physical and chemical properties on metabolism by identified enzymes

  • Evaluate correlations between in vitro metabolism and tissue clearance of RNA-based therapeutics.

  • Engage with RNA synthetic chemists, ADME scientists, bioanalytical chemists, protein biochemists and in vivo pharmacologists to interrogate lead this research effort.

  • Identify areas of key need across clinical development and champion creative solutions to address those needs. Maintain external awareness and learning to benefit the organization.

  • Present findings at conferences and publish in high quality peer-reviewed journals.

Basic Qualifications

  • PhD in biochemistry, chemistry, pharmacology, molecular biology or related fields.

  • Expertise in RNA or protein chemistry or biochemistry, enzymology, drug metabolism/biotransformation desired.

Additional Skills/Preferences

If you are described with these skills, you could be a great fit for the role:

  • Self-directed and highly motivated individual who wants to learn new techniques while continually pursuing research and publication goals.

  • Excellent communicator (oral and written) with presentation experience, along with a strong publication record.

  • Proficient in data analysis and reporting

  • Experienced with Tissue and cellular fractionation, Protein extractions, Western blotting/ELISA, proteomics, high throughput screening of enzyme activity,

  • Understanding of pharmacokinetics or mechanistic modeling

  • Basic knowledge of Microsoft Office, Graphpad Prism.

About Eli Lilly’s Postdoctoral Scientist Program

When it comes to research and development, our goal is to discover and deliver innovative medicines that make life better for people around the world. It’s challenging, expensive and often filled with failure. But even when we fail, we advance medical science and understanding by learning more about diseases, biology and chemistry – ultimately bringing new solutions one step closer to reality.

Over the course of our history, we have shed light on some of the toughest health care problems known to man – diabetes, heart disease, infectious diseases, neuroscience disorders, cancer and more. We could not pursue this without our research and development team.

Postdoctoral scientists help us continue this pursuit. During your experience you will get:

  • Top industry research experience

  • Mentoring by some of Lilly’s top scientists

  • Laboratory and classroom training and education to further your development

  • Collaboration and networking across dozens of postdoctoral scientists and other researchers

Additional Information

This position is not permanent. It is for a fixed duration of two years with potential to extend to 3 years and for maximum of up to 4 years. You will have opportunities to apply for full time positions after your duration is complete.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.