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Lilly Post Doctoral Scientist in Indianapolis, Indiana

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Company Overview

Lilly, a leading innovation-driven corporation is developing a growing portfolio of pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, Indiana, Lilly makes life better – through medicines and information – for some of the world’s most urgent medical needs. Founded over 145 years ago, the company has sustained a culture that values excellence, integrity, and respect for people. This has resulted in Lilly frequently being ranked as one of the best companies in the world at which to work. Lilly knows its business has prospered because of its employees – people with a talent for innovation and a passion for making a difference by finding treatments for the most stubborn diseases; people whose talent is matched by their generosity, and people with strong values and a determination to prevail, regardless of the challenges. Join our team – and make a difference in improving health for people all over the world.

Position Overview

The Post-Doctoral Scientist modernizes and improves the analytical control strategy of protein drug substances. This includes the application of mass spectrometry to improve the current business and support the commercialization of new molecules.

The position is a Post-Doctoral scientist position in the Analytical Sciences organization. The position will be made available beginning Nov 1, 2021 and will provide technical and scientific support within a dynamic manufacturing environment for development of commercial processes (synthesis and purification) for biomolecules including proteins, peptides, and oligonucleotides. The successful candidate will be responsible for designing and executing experiments to advance process knowledge, process optimization and production technical transfer, as needed. Scientists actively contribute to the Analytical Sciences organization, and have extensive opportunities for involvement in cross-functional teams. This position allows for development of a comprehensive understanding of the pharmaceutical industry, Good Manufacturing Practices (GMP), regulatory requirements, and the essential role scientists play in creating solutions for Eli Lilly and Company.

Key Objectives/Deliverables:

  • Understanding the scientific principles required for testing intermediates and drug substances.

  • Identify and support the implementation of new technologies/methods that offer significant advantages in cost reduction or process control. This includes expanding the use of mass spectrometry in a highly regulated environment.

  • Streamline analytical strategies to reduce the overall testing burden in terms of cost and/or time.

  • Develop methods to meet unmet control strategy needs.

  • Ensure the analytical control strategy from raw materials through drug substance is technically sound, cost effective, compliant, and sustainable.

  • Troubleshoot and investigate major analytical issues.

  • Align regulatory strategies that require analytical testing with the goal of streamlining and modernizing the analytical control strategy.

  • Strong technical writing and documentation of all work in an appropriate manner.

  • Mentor lab associates to enhance their technical capabilities.

  • Participate in technology transfer as needed.

Basic Requirements:

  • Ph.D. in scientific disciplines of Chemistry, Biochemistry, Biology, or related fields.

  • Experience with LC-MS and/or MS/MS instrumentation

Addition Skills/Preferences

  • Experience developing protein/peptide analytical chromatographic separations

  • Strong statistical skills

  • Familiarity with GC/MS

  • Strong scientific communication skills

  • Demonstrated record of scientific achievement

  • Demonstrated problem solving abilities

  • Ability to work well independently and collaboratively

  • Understanding of protein, peptide or oligonucleotide chemistry and/or characterization.

  • Experience with HRMS instrumentation

This position is not permanent. It is for a fixed term position up to a maximum of 4 years.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company. If you would like to request an accommodation for medical or religious reasons, you may do so at

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!