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Lilly Postdoctoral Scientist-Product Development in Indianapolis, Indiana

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. For more than 140 years, we have worked tirelessly to discover medicines that make life better. These discoveries start in Lilly Research Laboratories, where our scientists work to create new medicines that will help solve our world’s greatest health challenges. We explore how next generation therapeutics, new technologies, and data analytics can improve patient health and the healthcare system. We share a real passion for challenging conventional wisdom and creating an environment that embraces creative, break-through concepts.

We are looking for a highly motivated researcher to design techniques to assess in vivo supersaturation and precipitation for oral dosage forms. The project will build off published work by investigating multiple techniques and assembling methodology and workflows that improve upon current predictive abilities. The project proposes that the prediction of oral formulation performance for supersaturating dosage forms can be greatly improved by designing in vitro techniques and workflows that more accurately reflect the in vivo environment. The techniques will be designed to measure and characterize supersaturation and precipitation phenomena. These measurements, coupled with models, will provide a more mechanistic description of formulation performance. The approaches will be applied to conventional salts and solid form design as well as more advanced formulations like amorphous solid dispersions and emulsifying dosage forms.

Key objectives and deliverables:

  • Design experiments to measure in vivo relevant supersaturation and precipitation, building off techniques that have been previously published and those currently in use at Lilly

  • Utilize state of the art thermodynamic and kinetic models to describe supersaturation and precipitation phenomena

  • Define methodologies such that they will readily interface with current in silico oral absorption models. The coupled in vitro techniques and in silico models will be used to make predictions of in vivo formulation performance.

  • Investigate sensitivity of the techniques to important experimental parameters (fluid composition, residence time, mixing dynamics, degree of supersaturation, scale). Refine the techniques based on findings

  • Validate the approach using: 1) Published animal and human data on well-studied drugs and formulations and 2) Lilly pharmacokinetic animal and human data, where in vivo supersaturation and precipitation can be inferred through model-based prediction of plasma concentrations

  • Effectively integrate cross-functional information within Synthetic Molecule Design and Development and apply technical knowledge to data-driven decision making

  • Focus on defining clear scientific hypothesis, goals and fit-for-purpose experimental plans and timelines in support of advancing the Lilly portfolio

  • Contribute to the general scientific community through external publications and presentations

  • Keep abreast of relevant scientific literature/new technologies/capabilities

  • Ensure activities are aligned with all relevant Development Quality, safety requirements and Team Lilly expectations

Basic Qualifications:

  • Ph.D. in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or related field

Additional Skills/Preferences:

  • Knowledge and experience in oral absorption and biopharmaceutics

  • Knowledge and experience with supersaturation and precipitation phenomena as related to oral dosage form performance

  • General knowledge of analytical measurements and techniques, including UV/Vis and/or HPLC

  • Solid grasp of modeling methodology used to describe oral absorption and related physical processes

  • Experience in instrument/measurement design and software control

  • Familiarity with oral absorption modeling tools, including commercial software packages

  • Proficiency in computer programming languages and computational techniques

  • Excellent problem solving and decision-making skills

  • Demonstration of scientific leadership skills

  • Effective oral and written communication skills

  • Must be able to work productively in an interdisciplinary team environment.

Additional Information:

  • This position is not permanent. It is for a fixed duration of 2 years with the potential to extend annually for up to 4 years.

  • The position is governed by regulations including OSHA, AAALAC, OLAW and NRC — compliance to all applicable regulations is mandatory.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide valid proof of vaccination to the company.

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!