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Lilly Principal Research Scientist-ADME/Drug disposition in Indianapolis, Indiana

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Do you have a detailed understanding of pharmacokinetics, ADME and proficiency to communicate theory and concepts clearly? Lilly’s Drug Disposition team is searching for an experienced pharmaceutical scientist to lead in the application of absorption, distribution, metabolism, excretion (ADME) science to advance our portfolio. Working on cross-functional teams, we are a diverse and multidisciplinary group, utilizing in vitro, in vivo, and in silico approaches to mechanistically study the pharmacokinetics, absorption, and disposition of new chemical entities. You will serve as a technical leader within the department and across portfolio cross-functional teams. This role will require engaging in experimental design and data interpretation to deliver the discovery and development portfolio of investigational targets and novel therapeutics. We are passionate about making an impact in the lives of our patients, their families and our communities. Consider joining our team!


  • Accountable for the delivery of scientifically integrated data packages to guide compound selection, study design, portfolio decisions, and regulatory submissions.

  • Partner with cross-functional colleagues in both Discovery and Development (eg. Toxicology, Pharmacology, Chemistry, Clinical PK/PD, Clinical Pharmacology, Regulatory, and Medical) to assess drugability and optimize ADME properties to deliver drug candidates to the clinic.

  • Design and support nonclinical and clinical studies, supporting global registration packages.

  • Lead R&D initiatives to grow and develop ADME/DMPK capabilities across experimental and drug modalities.

  • Integrate in vitro, in vivo, and in silico ADME data with Biology and Chemistry understanding to define structure-activity- and structure-property-relationships and deliver favorable molecular and experimental design strategies.

  • Prepare data packages to support global regulatory submissions and correspondence as well as represent ADME in face-to-face discussions with regulators.

  • Guide junior, peer, and upper level scientists in best and modern practices of multi-property optimization through the use of mechanistic ADME principles.

  • Evaluate and apply innovative PBPK approaches to translate and predict human PK, using modeling as a tool to help generate hypotheses, design better studies, inform clinical plans and support registration.

  • Communicate the value of mechanistic ADME approaches both internally within R&D and externally including regulatory agencies.

  • Build a strong external network (e.g. academia, consortia) and keep up to date with emerging literature and science in the area.

Basic Qualifications

  • Ph.D. degree in Pharmaceutical Sciences, Pharmacokinetics, or related field with at least 5 years of experience in the field of drug metabolism and disposition or clinical pharmacology

Additional Skills/ Preferences

  • Experience in drug discovery and development.

  • Ability to balance multiple projects and handle competing responsibilities.

  • Hands-on experience with modeling software (e.g. SimCYP, GastroPlus, NONMEM, Matlab etc.).

  • Demonstrate strong communication skills with the ability to integrate diverse perspectives, adroitly deliver critical messaging, and influence leaders/key partners.

  • Collaborative team behaviors and aspiration to build and sustain relationships with R&D customers and the wider scientific community.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!