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Lilly Principal Research Scientist-RNA Therapeutics in Indianapolis, Indiana

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Responsibilities :

Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Our RNA Therapeutics team is an innovation-focused organization striving to identify, develop and apply the most cutting edge technologies to deliver maximum benefit to our patients. Our agile and diverse team strives to operate as an autonomous ‘biotech-like’ company within the walls of Lilly.

In the RNA Team, both basic and applied sciences are vital. We are looking for creative and energetic problem solvers to lead in a multidisciplinary team at the front edge of innovation. Key facets of the role are identifying next generation tissue opportunities, leading teams in design of ligands for specific cellular and tissue delivery and synthesis and purification for sophisticated molecule assembly that progress an innovative preclinical portfolio with focus on scientific precision and portfolio effectiveness. We are building state-of-the art expertise in major oligonucleotide-based modalities and delivery approaches, with an emphasis on innovative approaches with potential for breakthrough efficacy.

You will join our fast-paced, interdisciplinary team as we utilize novel RNA/oligonucleotide based therapeutic modalities to enhance the Lilly portfolio. The successful applicant will utilize their knowledge and technical expertise to complement and enable core capabilities and help drive the revelation and development of RNA-based clinical candidates. Do you have an aptitude for innovative approaches and modalities in discovery and development focused on identifying impactful therapies for the patient? We want you on our team!

Basic Qualifications :

  • PhD in Chemistry, Biochemistry or related discipline with 5+ yrs of relevant experience preferably in oligonucleotide chemistry

Additional Skills/Preferences :

  • Strong experience in solid-phase RNA/DNA synthesis, process development and optimization

  • Expertise in the purification and analytical techniques for oligonucleotides, and oligonucleotides conjugates with small molecules, lipids, carbohydrates and peptides

  • Demonstrated scientific, analytical and synthetic capabilities to craft and deliver diverse nucleotides and related analogs while utilizing information from diverse sources and using novel technologies.

  • Demonstrated ability to multitask efficiently, prioritize quickly and execute/troubleshoot designs to conclusion.

  • Demonstrated flexibility and ability to engage scientifically in new areas rapidly, demonstrating initiative and appropriate risk-taking.

  • Awareness and connections in the external environment.

  • Strong communication skills and ability to influence others to promote a positive work environment.

Information for Internal Employees :

If you are currently in a technical path role, but outside of the posting band, you may apply. You will be hired at your current level. For example: Current P4 (tech ladder), Posting R1-2 tech ladder, hire will occur at P4

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!