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Lilly Research Advisor - ADME in Indianapolis, Indiana

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

We are growing! Lilly is on the forefront of ground breaking research and has established the Lilly Institute of New Genetics Medicine. The Biotechnology Research/ADME-PK group is looking for scientists interested in pioneering novel drug modalities to join us in this effort. We seek dynamic, energetic, collaborative scientists to work on life-changing therapies for patients involving novel complex molecules including DNA and RNA-based technologies. You will have the opportunity to engage with diverse teams in a ‘biotech-like’ manner within the walls of Lilly where innovative ways of thinking are essential to advance these innovative platforms. To meet this changing environment, we are expanding our teams in Indianapolis and Boston to enable strong cross functional teamwork.

The Biotechnology Research/ADME group is responsible for evaluating the preclinical pharmacokinetics and disposition of complex molecules including gene therapies, siRNA, therapeutic proteins/peptides and monoclonal antibodies. Our diverse team collaborates with toxicology, discovery biology, protein engineering and multiple therapeutic areas to help identify and characterize optimal therapeutic candidates to advance through clinical testing. The group is growing capabilities in analytical, cell biology and PK/PD to more fully characterize factors influencing the absorption and disposition of biologic therapeutics, so we are looking for candidates with diverse skills including experience in molecular biology, siRNA, immunochemistry, gene editing, and clinical development.

Responsibilities in this role:

  • Individual scientific contributor to function as an ADME subject matter authority in multidisciplinary team environments with primary responsibility for the early preclinical development of innovative molecules (siRNA, antibodies, fusion proteins, drug conjugates)

  • Integrate pharmacokinetics and PK/PD with discovery biology to define structure activity relationships to guide engineering strategies and help optimize development of protein and genetic therapeutics

  • Interact across groups, including other departments, regulatory agencies, and functional teams within drug disposition

  • Responsible for the design, conduct, interpretation and reporting of study results

  • Contribute to strategic workflows to streamline molecule selection and evaluation

  • Experienced with ADME development phase support, including preparation of regulatory briefing documents, IND, investigator brochures, non-clinical and clinical study protocols, and study reporting.

Do you have demonstrated ability to identify scientific issues and solve problems, both individually and with partners in functional groups? We would love to have you on our team! Apply today and join the Lilly family!

Basic Qualifications:

Ph.D. in Pharmacology, Biochemistry, Molecular Biology, Pharmaceutical Sciences, or a related field with 2+ years of experience in the discovery and development of biological-therapeutics.

Additional Skills/Preferences:

  • Industry (Pharma/Biotech) experience in the preclinical evaluation of biologics and/or hybrid modalities

  • Experience working with oligonucleotide-based therapeutics

  • Experience contributing in an interdisciplinary team and working in a matrixed work environment

  • Strong scientific and analytical skills.

  • An understanding and/or experience with immunoassay and/or LC/MS bioanalytical methodology

  • Demonstrated ability to multitask efficiently, prioritize quickly and bring projects to conclusion.

  • Have a track record of leadership of scientific rigor and excellence.

  • Excellent oral and written skills.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( LillyRecruitingCompliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

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