Lilly Research Scientist - ADME in Indianapolis, Indiana
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
Do you have knowledge of properties and/or enzyme systems responsible for absorption, distribution, metabolism, and excretion of xenobiotics? We are excited to be enhancing our capabilities in our ADME organization. Lilly is seeking a technical leader to lead all aspects of the creation and operation of an ADME in vitro screening laboratory. This role will be integral to the advancement of our small molecule discovery portfolio. The ideal scientist will design, develop, and implement high-throughput in vitro assays optimized to speed data delivery. The successful candidate will have good laboratory, analytical, automation and project management skills as well as an understanding of drug disposition (ADME) science.
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Key Roles & Responsibilities:
Create in vitro laboratory which includes collaborations with facilities, health and safety and technical experts.
Develop, validate, implement and/or approve appropriate analytical or enzymatic assays and methods including, but not limited to, CYP450 inhibition, plasma stability, solubility, and microsomal clearance.
Responsible for the design, conduct, analysis, interpretation, documentation and/or reporting of studies.
Develop framework and optimize flow of work from compound submission to data readout
Evaluate new technologies, techniques, study designs or equipment and assess the applicability to optimize productivity.
Understand application of ADME screening data within discovery and apply such knowledge improve assays and/or design and development novel assays.
Perform administrative tasks associated with laboratory safety, maintenance, and operation.
Serve as QC/QR reviewer for data notebooks and documents
Supervise scientific activities of associate and technician level scientists.
PhD in relevant scientific area or MS degree with a minimum 7 years or BS degree with minimum 10 years of relevant experience in biology, pharmacology, chemistry, or related field
Additionally, preferred skills will include:
Analytical experience including operation of triple quad mass spectrometers
Experience in cell culture of mammalian cell lines
Experience with high throughput automation
Ability to rapidly learn new concepts and to work independently to develop assays/methods.
Strong written, verbal communication and project management skills
Demonstrated results/experience in work on interdisciplinary teams.
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At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people. We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!