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Lilly Research Scientist - ADME in Indianapolis, Indiana

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Do you have knowledge of properties and/or enzyme systems responsible for absorption, distribution, metabolism, and excretion of xenobiotics? We are excited to be enhancing our capabilities in our ADME organization. Lilly is seeking a technical leader to lead all aspects of the creation and operation of an ADME in vitro screening laboratory. This role will be integral to the advancement of our small molecule discovery portfolio. The ideal scientist will design, develop, and implement high-throughput in vitro assays optimized to speed data delivery. The successful candidate will have good laboratory, analytical, automation and project management skills as well as an understanding of drug disposition (ADME) science.

We're looking for a scientific leader who can find creative solutions to complex problems. Apply today! We want you on our team!

Key Roles & Responsibilities:

  • Create in vitro laboratory which includes collaborations with facilities, health and safety and technical experts.

  • Develop, validate, implement and/or approve appropriate analytical or enzymatic assays and methods including, but not limited to, CYP450 inhibition, plasma stability, solubility, and microsomal clearance.

  • Responsible for the design, conduct, analysis, interpretation, documentation and/or reporting of studies.

  • Develop framework and optimize flow of work from compound submission to data readout

  • Evaluate new technologies, techniques, study designs or equipment and assess the applicability to optimize productivity.

  • Understand application of ADME screening data within discovery and apply such knowledge improve assays and/or design and development novel assays.

  • Perform administrative tasks associated with laboratory safety, maintenance, and operation.

  • Serve as QC/QR reviewer for data notebooks and documents

  • Supervise scientific activities of associate and technician level scientists.

Basic Qualifications:

PhD in relevant scientific area or MS degree with a minimum 7 years or BS degree with minimum 10 years of relevant experience in biology, pharmacology, chemistry, or related field

Additionally, preferred skills will include:

  • Analytical experience including operation of triple quad mass spectrometers

  • Experience in cell culture of mammalian cell lines

  • Experience with high throughput automation

  • Ability to rapidly learn new concepts and to work independently to develop assays/methods.

  • Strong written, verbal communication and project management skills

  • Demonstrated results/experience in work on interdisciplinary teams.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company. If you would like to request an accommodation for medical or religious reasons, you may do so at

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!