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Lilly Research Scientist / Senior Research Scientist - Oligonucleotide Chemistry in Indianapolis, Indiana

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Our RNA Therapeutics team is an innovation-focused organization striving to identify, develop and apply the most groundbreaking technologies to deliver maximum benefit to our patients. Our agile and diverse team strives to operate as an autonomous ‘biotech-like’ company within the walls of Lilly.

In the RNA Team, both basic and applied sciences are vital. We are looking for creative and energetic problem solvers to lead in a multidisciplinary team at the front edge of innovation. Key facets of the role are identifying next generation tissue opportunities, leading teams in design of ligands for specific cellular and tissue delivery and synthesis and purification for sophisticated molecule assembly. These will progress an innovative preclinical portfolio with focus on scientific precision and portfolio effectiveness. We are building state-of-the art expertise in major oligonucleotide-based modalities and delivery approaches, with an emphasis on innovative approaches with potential for breakthrough efficacy.

You will join our fast-paced, interdisciplinary team as we apply novel RNA/oligonucleotide based therapeutic modalities to enhance the Lilly portfolio. The successful applicant will use their knowledge and technical expertise to complement and enable core capabilities and help drive the revelation and development of RNA-based clinical candidates. Do you have the skills for creative approaches and modalities in discovery and development focused on identifying impactful therapies for the patient? We want you on our team! Apply today and help us take novel therapeutics to the next level!

Basic Qualifications:

  • PhD in chemistry, pharmaceutical sciences or related field with a minimum of 2 years of experience post degree (can include postdoctoral training

  • Experience in siRNA or antisense oligonucleotide technologies preferred

Additional Skills/Preferences:

  • Experience in the design, synthesis of novel nucleoside/nucleotide chemistry and their application in oligonucleotides

  • Knowledge of oligonucleotide design for application in new modalities such as siRNA, ASO etc.

  • Proficiency and deep understanding of modern synthetic methods used in the solid phase oligonucleotide synthesis such as phosphoramidite, H-phosphonate chemistry etc.

  • Contribute to multiple projects as a project team lead and as a senior member and advance Lilly’s new modalities oligonucleotide portfolio

  • Collaborate with scientists to maintain Oligo synthesizers, HPLC and desalting units in the laboratory

  • Excellent communication skills with a proven track record of scientific excellence as evidenced by strong publication record

  • Confident, execution focused and team oriented with an ability to thrive in an entrepreneurial environment

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As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).