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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Biotechnology Discovery Research (BioTDR) organization within Lilly Research Laboratories spans target identification to clinical candidate selection. The Lead Optimization Core group within BioTDR is seeking an innovate, technical expert in molecular biology, cell culture and AAV gene therapy. The successful candidate will join a diverse, interdisciplinary team that applies their extensive knowledge in expression, purification, and characterization to deliver innovative approaches to support the discovery and optimization of a wide array of therapeutic modalities including antibodies, fusion proteins, bispecifics, multi-specifics, bioconjugates, ADCs and AAV products. Are you eager to drive innovation in a fast-paced, collaborative environment?

This is an exciting, intellectually stimulating opportunity for a scientist with deep technical expertise and strong interest in solving technically challenging problems, advancing science and technologies, and who also thrives in a highly collaborative environment.

Responsibilities:

• Champion the advancement of the AAV viral vector production and purification platform through creative solutions including technology scouting and DoE experiments to accelerate gene therapy programs.

• Work closely with AAV genome and capsid engineering teams to explore and implement platform and project-specific enhancements.

• Provide technical updates of project progress and coordinate next-step activities in collaboration with management.

• Establish effective partnerships with cross-functional teams in the Discovery and Development areas to enable the development of current and new therapeutic modalities.

• Work with a high level of technical and strategic autonomy to deliver impactful results and drive Discovery projects to key decisions and milestones.

• Maintain external awareness of advancements in the field of gene therapy through literature, forums, and conferences.

• Develop talent within the team through technical mentorship of junior scientists and potential supervisory responsibilities to foster their growth and development.

Basic Qualifications:

• PhD in Molecular Biology, Biochemistry, Chemical Engineering, Biotechnology, or related field.

• 3+ years of relevant industry experience in molecular biology and cell culture development. Demonstrated competency, experience, and knowledge with new therapeutic modalities including AAV gene therapy.

Additional Skills/Preferences

• Extensive hands-on experience with both upstream and downstream production of recombinant proteins, AAV vectors and/or other new therapeutic modalities in an industrial setting.

• Strong core proficiency in molecular biology and protein biochemistry with experience in various protein purification and characterization techniques.

• Proven ability to work cross-functionally, effectively plan and prioritize work activities and strong adaptability to meet evolving needs as priority plan changes.

• Mammalian cell engineering (CRISPR/Cas9) and fermentation optimization, including the optimization of expression/production processes for biologics.

• Proficient in data analysis and reporting (Excel, JMP, GraphPad Prism, Benchling, etc.)

• Effective interpersonal and communication skills; mentoring, providing constructive feedback and cultivating an environment for learning and discovery.

• Excellent communicator (oral and written) with presentation experience, along with a strong publication record.

• Previous experience with supervising direct reports or performance management.

• Exceptional problem solving and decision-making skills.

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