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Lilly Senior Systems Engineer in Indianapolis, Indiana

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

In 1992, Eli Lilly and Company established the Delivery, Device, and Connected Solutions (DDCS) business for the purpose of creating, developing, launching and refining proprietary delivery device systems. This business is unique to the broader Lilly Research Labs organization due to its focus on patient centered delivery system solutions, its innovative approach to delivery platforms utilizing both internal and external technologies, and its level of integration with the commercial groups and Business Units.


Are you a highly inclusive leader and innovative problem solver? Do you relentlessly and passionately pursue breakthrough solutions for patients? We are seeking a highly motivated Systems Engineering (SE) leader to join our DDCS team. You will be a key leader of multi-functional teams comprised of various technical and functional players. You will develop and integrate capabilities across multiple, sophisticated systems and system of systems to provide seamlessly integrated connected device and digital health solutions.

Key responsibilities include the following:

  • Partner with key team members to elicit stakeholder needs, understand the context and environment, facilitate the deconfliction of requirements, spearhead trade analyses, and manage stakeholder expectations throughout the development lifecycle.

  • Create system architectures or portfolio architectures that incorporate flexibility, adaptability, modularity, and scalability to maximize reuse and interoperability.

  • Lead full lifecycle systems engineering activities.

  • Drive continuous process improvements and contribute to defining the strategic direction of the Systems Engineering field at Lilly.

  • Coach and lead a team of systems engineers; responsible for career and performance development, training, staffing assignments, and eliminating blockers for team members.

  • Lead sophisticated programs serving as the single point of technical accountability for successful delivery of the solution(s).

Basic Qualifications:

  • Bachelor’s degree in a Science, Technology, Engineering, or Math (STEM) field with 10+ years of working experience

Additional Skills / Preferences:

  • Advanced degree preferred

  • 5+ years of engineering management or engineering functional management experience

  • Possesses a passion for systems engineering and has experience selling the benefits of systems thinking across the organization

  • Familiar with ISO 15288, ISO 14971, and experience with FDA class II or III medical device regulatory requirements with knowledge of drug product and medical device standards

  • Expert, hands on experience with systems engineering tools and processes. Familiarity with SysML, model-based systems engineering (MBSE), and feature-based Product Line Engineering (PLE) methodologies

  • Demonstrated success utilizing both structured (i.e. waterfall) and iterative (i.e. Agile, SAFe) system and system of systems development methodologies

  • Experience delivering innovative and optimized solutions that integrate multiple capabilities and technologies spanning various engineering disciplines

  • Exemplary soft skills and demonstrated ability to become an expert in the stakeholder's environment to effectively translate user needs into architectures and requirements

  • Demonstrated ability to work effectively across boundaries, and effectively influence without authority to drive organizational culture change

  • Excellent written and verbal communication skills, able to effectively interact and influence both business and technical leaders

  • INCOSE certified Systems Engineering Professional (ASEP, CSEP, ESEP)

Additional Information:

  • Primary location is at Lilly Technology Center – North, Indianapolis, IN

  • Secondary location is remote work from home

  • Ability to travel up to 10% of the time

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!