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Loxo@Lilly Scientist, Cell Line Generation (Contract) in Louisville, Colorado

About Loxo@Lilly:

Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.

Position Summary:

We are looking for a highly capable and motivated laboratory-based scientist experienced in cell line generation and characterization. This individual will be a part of the cell line engineering/cell biology team that generates engineered cell lines for our preclinical programs in oncology. The primary responsibilities will include engineering cell lines for use in in vitro mechanistic assays and studies. The right candidate is expected to work within a collaborative team environment, while being able to work independently to design, execute, and optimize experiments. Beyond performing experiments, the scientist will analyze the data from experiments, present the data in meetings and work with the rest of the team to determine the next steps.

Roles and Responsibilities of the Position:

  • Maintain cultures of frequently used suspension and adherent cell lines.

  • Deposit and archive cell lines in the company’s repository cell line bank.

  • Keep detailed and accurate laboratory records, present results at group meetings and project team meetings.

  • Viral titer measurement, and viral stock maintenance.

  • Perform routine molecular and cell biology techniques like DNA/RNA/protein extraction, qPCR analysis, western blot analysis, fluorescent microscopy and so on.

  • Construct knockout and expression vectors using mammalian plasmid and lentiviral, adenoviral, or retroviral systems.

Required Qualifications and Preferred Background:

  • Required:

  • BA/BS/MS in biology, cell biology, molecular biology or a related field and 0-3 years of experience with basic tissue culture techniques such as cell propagation, cryo- preservation, maintenance and so on.

  • Must be organized and efficient and able to work according to timelines.

  • Ideal candidate will also have:

  • Prior cell culture experience with immortalized cell lines, cancer cell lines and/or primary cells

  • Experience creating stable cell lines, transient transfections, viral transductions

  • Experience with performing qPCR, ELISA, western blot, flow cytometry, and cell sorting, all in the context of mammalian cells. Fluorescent microscopy experience would be a plus.

  • A high level of proficiency with many kinds of scientific software used to operate lab equipment and/or the ability to quickly master new software

  • Experience and proficiency with data analysis using statistical software such as Excel, Prism, Spotfire or others

  • Pharma/biotech drug discovery experience a plus

Physical Demands/ Travel:

The physical demands of this job are consistent with laboratory bench setting and light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a laboratory-based setting.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.