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Loxo@Lilly Senior Associate Scientist/Scientist, Cell Biology in New York, New York

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Senior Associate Scientist/Scientist, Cell Biology will be part of the Loxo@Lilly’s Discovery Signaling group in Alexandria Center, NY. The Discovery Signaling group is responsible for identifying molecular targets for life-changing oncology drugs, establishing the cellular reporters for onco-pathways and investigating the mechanism of actions of novel drug candidates with a focus on small molecule drugs, and providing forward-thinking approaches to advance our clinical portfolio.

The Senior Associate Scientist/Scientist, Cell Biology will be responsible for creating and evaluating cellular models, assays, execution strategies to quantitatively determine the potency and selectivity of small molecule compounds and interrogate signaling pathways. This is a hands-on position for an experienced lab scientist who enjoys working in the lab. This scientist must have excellent people skills and be able to work with a positive, “can-do” attitude in a dynamic, fast-paced, team environment focused on high quality science to deliver innovative cancer drugs.

Roles and Responsibilities of the Position:

  • Create, develop and validate quantitative mammalian cellular assays to address the project team’s mechanistic and functional needs.

  • Establish engineered cell models to determine the actions of drugs on the specific oncogenic signaling.

  • Collaborate with colleagues throughout the company to ensure assays meet the program needs and results are appropriately interpreted.

  • Prepare reports for internal and external purposes including regulatory submissions.

  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies.

  • Develop and continually advance one’s knowledge base on the molecular pathways being targeted by our clinical and research programs.

  • Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way.

Required Qualifications and Preferred Background:

  • BS degree with 5+ years experience, MS degree with 3+ years experience or PhD with 1+ years experience in Molecular/Cellular Biology, Biochemistry, or related field with 2+ years hands-on molecular biology and cell assay experience in a biotech/pharma setting or BS/MS in Molecular/Cellular Biology or Biochemistry with 3+years hands-on molecular biology and cell assay experience in a biotech/pharma setting.

Ideal candidate will also have:

  • Experience in culture cancer cell lines and/or patients-derived primary tumor cells, in both 2D and 3D system.

  • Demonstrated hands-on experience in flow cytometry-based cell analysis and cell sorting.

  • Experience in creating, developing, and running cellular assays; engineering cell lines to express or knock-down genes of interest, interrogating cellular signal transduction pathways, and characterizing kinase activity.

  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.

  • Highly organized with excellent analytical, documentation and multi-tasking skills. Proficient in Microsoft Office suite and applications.

  • Good and thoughtful listener who values collaboration.

  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Scientist level could range from between $59,000 to $86,577 and that the base salary for the Scientist level could range from between $78,000 to $114,498 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

This position’s work environment is in a lab/bench environment.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.