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Loxo@Lilly Senior Principal Scientist/Scientific Lead, Discovery Signaling in New York, New York

About Loxo@Lilly:

Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.

The Senior Principal Scientist/Scientific Lead will be a member of the Loxo Oncology Discovery Signaling team in the Alexandria Center, NYC. The Discovery Signaling team is responsible for characterizing the oncogenic rewiring of signal transduction pathways in cancer cells for the development of novel therapeutic approaches to benefit patients with high medical need. The team collaborates closely with other Discovery teams and works hand-in-hand with the Translation Sciences and Clinical Biomarker functions to support the clinical development of groundbreaking new cancer medicines.

This is a hands-on position for an experienced lab scientist, who enjoys working at the bench and applying state-of-the art technology platforms. The successful candidate should have excellent people and communication skills, and exhibit a positive, “can-do” attitude in a dynamic, fast-paced team focused on rigorous and high quality science to deliver innovative cancer drugs. The focus is on small molecule drugs and providing forward-thinking approaches to advance our clinical portfolio.

*Roles and Responsibilities of the Position:

  • Develop and validate quantitative molecular and mammalian cellular assays to address mechanistic and functional questions in pre-clinical studies.

  • Design and execute key experiments to evaluate compounds, identify combination partners and investigate drug resistance.

  • Identify and characterize new targeting nodes in pathway network of interest to inform novel treatment in cancer and broaden strategies for combination therapy or overcoming resistance.

  • Complete and effectively manage tasks according to the highest scientific standards and in a timely manner.

  • Participate in and present in project meetings to ensure assays meet the program needs and results are appropriately interpreted.

  • Collaborate with different functional teams throughout the company to guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies.

  • Prepare scientific reports and present results at internal and external meetings.

  • Proactively investigate new technologies, methods, and evaluate service providers to ensure the work is conducted in a scientifically sound, efficient, and timely manner.

  • Develop and continually advance one’s knowledge base on the molecular pathways and the therapeutic areas being targeted by our clinical and research programs.

Required Qualifications and Preferred Background:

  • Required:

  • PhD in Molecular/Cellular Biology or Biochemistry, or related field with either:

  • o 0-5 years hands-on molecular and cell biology experience in a post-doctoral/research/industry setting

  • BS/MS in Molecular/Cellular Biology or Biochemistry with:

  • o MS with 6+ years hands-on molecular and cell biology experience in a biotech/pharma setting or BS with 8+ years hands-on molecular and cell biology experience in a biotech/pharma setting.

  • Experience in developing, conducting, troubleshooting molecular and cellular assays; engineering cell models to modulate gene expression, interrogating cellular signal transduction pathways, and characterizing enzymatic activities. Experience with primary cell models, co-culture systems or cell imaging is a plus.

  • Experience with general molecular biological techniques including cell-based functional assays, vector engineering, cloning and mutagenesis, qRT-PCR, ELISA, MSD and gel electrophoresis, Western Blotting, Immunoprecipitation/Co-IP, NGS platforms, FACS etc.

  • Strong background in experimental quantitative analyses and statistics (GraphPad Prism).

  • Broad knowledge and in-depth understanding of signal transduction pathways in cancer.

Ideal candidate will also have/be:

  • Highly organized with excellent documentation and outstanding problem-solving/multi-tasking abilities

  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.

  • Committed to staying up to date on the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.

  • Good and thoughtful listener who values collaboration.

  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies.

  • Publications in peer-reviewed scientific journals and external/internal presentations are expected.

  • Proficient in Microsoft Office suite and applications.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Principal Scientist level could range from between $109,500 to $160,600 and that the base salary for the Scientific Lead could range from between $120,000 to $176,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands/ Travel:

The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab/bench environment.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.