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Lilly Advisor-Cryo-Electron Microscopy Research Scientist in San Diego, California

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Our Global Structural Biology group at the Lilly Biotechnology Center (LBC) in San Diego is looking to add to our diverse and dynamic team of scientists in the area of Cryo-Electron Microscopy. We are a part of Lilly’s Discovery Chemistry and Research & Technologies Division and responsible for gene-to-structure workflows supporting Lilly’s drug discovery pipeline. Do you have a strong work ethic, scientific curiosity, and track record of cross-functional teamwork? We'd love you to bring your talents to Lilly! Apply today!

Responsibilities for the position

  • Provide cryo-electron microscopy support for a broad range of targets across therapeutic areas, and help drive the expression, purification and cryo-EM structure determination of novel drug targets, particularly membrane proteins

  • Partner closely with other structural biologists, biophysicists, protein biochemists and medicinal chemists to develop integrated approaches and address project specific needs and challenges

  • Collaborate on multidisciplinary teams, presenting scientific data in support of drug discovery projects

  • Support maintenance and basic troubleshooting of in-house microscopy equipment

  • Establish computational workflows for the processing of EM data and refinement of biomolecular structures

  • Provide training to Structural Biology colleagues on EM grid preparation, data collection and analysis

Basic Qualifications

  • PhD in Structural Biology, Biophysics, Biochemistry, Chemistry, or other applicable field with at least 2 years (post degree completion; can include postdoc) relevant experience

  • A strong publication record is highly preferred

Additional Skills/Preferences

  • Proven practical research experience in structure solution of membrane proteins by cryo-Electron Microscopy and membrane protein biochemistry

  • Experienced in Single Particle Analysis and cryo-EM structure determination of challenging targets, and familiarity with the major packages including RELION, cisTEM, and cryoSPARC

  • Flexibility to work in an environment with rapidly changing priorities and time frames, with strong interpersonal, written, and verbal communication and problem-solving skills

  • Experience in the biotech or pharma sector

  • Experience in X-ray crystallography, other biophysical methods (E.g., MS, SPR, MST, X-ray, EM, etc.) is a plus

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As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).