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Lilly Advisor-Membrane Protein Biochemist in San Diego, California

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Discovery Chemistry & Technologies organization within Lilly Research Laboratories is a diverse and dynamic group seeking a highly skilled scientist to join the structural biology team. We support drug discovery for numerous innovative projects and are looking for qualified scientists for structural biology efforts of challenging drug discovery targets including GPCRs and membrane proteins. We are a diverse team of scientists and strive for excellence and innovative solutions to find therapies for our patients. Join our team today and make an impact! Do you have experience leading and collaborating in a team environment? Consider joining Lilly today help to make a difference in our purpose and communities we serve!


The individual will work with diverse team of scientists and will be responsible to employ groundbreaking technologies to advance structural biology activities for GPCRs and protein complexes to drive SBDD efforts. Broad experience with membrane protein biochemistry is required.

  • Purify challenging GPCR and membrane protein complexes, as well as soluble protein complexes.

  • Use state-of-the-art biochemical, biophysical, and computational approaches to accelerate generation of high-quality reagents for crystallization and CryoEM studies.

  • Partner closely with other structural biologists, biophysicists, protein biochemists and medicinal chemists to develop integrative approaches and address specific project needs and challenges.

  • Collaborate on multidisciplinary teams designing novel therapeutics, presenting scientific data in support of drug discovery projects.

Basic Requirements:

PhD degree (or BS or MS with 10+ years of experience) in Structural Biology, Biophysics, Biochemistry, Chemistry or other relevant field.

Additional Skills/Preferences:

  • Comprehensive experience in membrane protein manipulation in detergent-free environments (nanodiscs, amphipols, etc.) is a plus.

  • Prior industry experience and a strong publication record is highly preferred.

  • Experience in both X-ray crystallography and cryo-EM is advantageous.

  • Flexibility to work in an environment with constantly evolving priorities and completion timelines, with strong interpersonal, written & verbal communication, and problem-solving skills.

  • Strong capability to collaborate with scientists in multiple fields.

  • Familiarity with other biophysical methods (E.g., MS, bioNMR, SPR, BLI, etc.) would be helpful.

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As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).