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Lilly Advisor-Molecular Biology/Gene Expression Scientist in San Diego, California

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Discovery Chemistry & Technologies organization within Lilly Research Laboratories is a diverse and dynamic group seeking a highly skilled scientist to join the structural biology team. We support drug discovery for numerous innovative projects and are looking for qualified scientists with expertise in recombinant protein expression. The individual will work with diverse team of scientists and will be responsible to implement gene-to-protein workflows for challenging drug discovery targets including GPCRs and membrane proteins. Broad experience and proven track record with E. Coli and Insect cell (Baculovirus-BV) expression systems is required for this position. We are a diverse team of scientists and strive for excellence and innovative solutions to find therapies for our patients. Consider joining Lilly today to make an impact and make a difference in our purpose and communities we serve!

Do you embrace diversity of thought, backgrounds, and experience to deliver innovative solutions? We would welcome you here at Lilly!

Responsibilities:

  • Design clones to produce diverse drug discovery targets, and research reagents using prokaryotic and eukaryotic expression systems. This includes construction of clones with complicated fusions, mutations, multiple tags and cleavage sites etc.

  • Innovate to develop core technologies and apply state-of the art technologies to achieve success in delivering needed molecular biology reagents to support drug discovery efforts.

  • Experience in basic molecular biology cloning, sequence analysis, tissue culture, baculovirus virus production, small scale expression and solubility analysis is required.

  • Experience in large scale fermentations (WAVE and flasks) of insect (BV) and mammalian cells is preferred

  • Partnering closely with other structural biologists, biophysicists, protein biochemists and in vitro pharmacologists to develop integrative approaches and address specific project needs and challenges

  • Interpret experimental data, along with observations from the literature, to provide innovative solutions to project teams.

  • Communicate experimental data and key findings to project teams

  • Contribute to scientific projects where solutions are developed through teamwork.

Basic Requirements:

  • Ph.D. in Molecular Biology, Biophysics, Biochemistry, Structural Biology, or other relevant field or

  • B.Sc or M.Sc with 7+ years of applicable experience in relevant field mentioned above is required (preferable industry experience).

Additional Skills/Preferences:

  • Experience in mammalian expression system

  • Experience in Bac Mam expression system

  • Experience in recombinant protein purification and structural biology is advantageous

  • Experience highly preferred in direct evolution to mutagenize protein targets to screen for improved thermostability, expression, and yield.

  • Comprehensive knowledge of GPCR biology and pharmacology will be a plus

  • Experience in development and screening of nanobodies and Fabs using yeast system

  • Experience in cell-free protein expression of human soluble and membrane proteins

  • Flexibility to work in a team environment with constantly evolving priorities and completion timelines, with strong interpersonal, written & verbal communication, and problem-solving skills

  • Strong capability to collaborate with scientists in multiple fields

  • Familiarity with gene-to-structure workflow

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( LillyRecruitingCompliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

#WeAreLilly

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!

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