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Lilly Director - Allosteric Modulation in San Diego, California

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Our Computational Chemistry and Cheminformatics (C3) group in DCRT is an innovation-focused global organization, combining human expertise and innovative computational technologies to benefit our patients. We are looking for an innovative scientist who can work collaboratively across multiple functions and geographic locations to help us discover novel small molecule therapeutics for our patients. You will work with experts in computational chemistry, pharmacology, medicinal chemistry, structural biology, antibody discovery, genetic medicines, and disease biology to discover and optimize small molecules for human testing.

Do you embrace diversity of thought, backgrounds, and have experience to deliver creative solutions? This is the type of leader we are looking for. Consider applying today and join the Lilly family of dedicated scientists and employees!


  • Innovate and implement new technologies to improve our ability to modulate “undruggable” targets and protein-protein interactions with small molecules

  • Collaborate with antibody and peptide discovery teams to identify and assess opportunities of using antibodies, antibody fragments and peptides as protein conformation-defining tools for small molecule drug discovery

  • Collaborate with target identification and enablement teams to identify and assess small molecule allosteric modulation opportunities, especially for targets with low ligandability

  • Contribute to the ligand identification strategy for allosteric modulators

  • Contribute to the strategy and execution of small molecule drug discovery programs, working closely with cross-functional project teams in a matrix environment

  • Champion and promote cross-modality collaboration

  • Mentor scientific staff and contribute to their scientific and career development

Basic Qualifications/Requirements

  • Ph.D. (with 5+ years) or BS and/or MS (with 12+ years) in Biology, Chemistry, Computational Chemistry, Structural Biology, or related field with drug discovery experience preferably in a biotech or pharma setting

  • Demonstrated impactful contributions to drug discovery programs as exemplified by authorship on peer-reviewed publications and/or inventorship on patents/patent applications

Additional Skills/Preferences

  • Experience in multiple therapeutic modalities, including antibody, antibody fragment, peptide, and small molecule

  • Experience in allosteric modulation of protein functions and protein-protein interactions

  • Demonstrated expertise in allosteric modulator identification and design in small molecule drug discovery programs as well as leading these programs/teams

  • Experience working cross-functionally with colleagues in multiple areas of discovery research

  • Expertise in Structural Biology and Structure-based Drug Design

  • Strong oral and written communication skills, organizational and leadership capabilities.

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As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).