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Lilly Postdoctoral Research Scientist-Immunology-FDE in San Diego, California

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Our team of outstanding researchers are seeking a Post-doctoral Research Scientist with a strong background in immunology and inflammatory diseases. The individual will carry out the research to help understand the role and mechanism of Fc gamma receptor binding of agonist Ab to checkpoint receptors for their agonist activities. These efforts will advance our innovative and groundbreaking science aimed to improve the lives of patients around the world.

Responsibilities:

We are looking for a scientist with experience studying immune cellular inhibitory receptor biology, signaling and cellular immunology. In addition to being suitable for publication, the work you pursue will involve understanding the mechanisms of action that drive the function and activities of therapeutic agonist antibody against inhibitory receptors in vitro and in vivo.

  • Investigate the human T cell biology including TCR signaling, co-receptor and inhibitory receptor signaling and cell proliferation

  • Characterize in vitro immune responses relevant to human autoimmune diseases. Perform flow cytometry characterization, analysis of gene expression and epigenetic change.

  • Single cell RNAseq and analysis of cellular transcriptomics.

  • Generate gene-edited cells with CRISPR-Cas9 technology.

  • Investigate the mechanism of action for inhibitory receptor agonist antibodies.

  • Understand the role of antibody Fc gamma receptors binding for agonism.

  • Actively collaborate with local external academic laboratories to source ideas, patient specimens, and technologies.

  • Record, analyze and communicate scientific ideas and data and also publish in peer-reviewed journal.

Basic Requirements:

PhD in Immunology, Molecular cell biology or related scientific field

Additional Skills/Preferences:

  • Deep expertise in working with primary human/rodent tissue/cells.

  • Knowledge and experience of in vivo pharmacology with various autoimmune/inflammatory disease models is a plus.

  • Cell-based assay development experience with special emphasis on functional genomic methods for target validation (e.g. shRNA, CRISPR-Cas9, flow cytometry).

  • Track record of scientific success proven by authorship on publications in excellent journals.

  • Independent research experience with innovative thinking and approaches for troubleshooting

  • Excellent work ethic

  • Great interpersonal skills

Additional Information:

This position is not permanent. It is for a fixed term position up to a maximum of 4 years. There will be opportunities to apply for full time positions at Lilly after your duration is complete.

About Eli Lilly’s Postdoctoral Scientist Program

When it comes to research and development, our goal is to discover and deliver innovative medicines that make life better for people around the world. It’s challenging, expensive and often filled with failure. But even when we fail, we advance medical science and understanding by learning more about diseases, biology and chemistry – ultimately bringing new solutions one step closer to reality.

Over the course of our history, we have shed light on some of the toughest health care problems known to man – diabetes, heart disease, infectious diseases, neuroscience disorders, cancer and more. We could not pursue this without our research and development team.

Postdoctoral scientists help us continue this pursuit. During your experience you will get:

  • Top industry research experience

  • Mentoring by some of Lilly’s top scientists

  • Laboratory and classroom training and education to further your development

  • Collaboration and networking with dozens of postdoctoral scientists and other researchers in both San Diego and Indianapolis sites

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( LillyRecruitingCompliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

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