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Lilly Principal Research Scientist - Protein Engineering in San Diego, California

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Do you possess strong protein engineering skills and have a vision to help build protein engineering platforms of the future? The Biotechnology Discovery Research group at Lilly’s Biotechnology Center in San Diego discovers medicines that address significant unmet needs by integrating biology with innovative scientific capabilities in protein engineering and computational sciences. We collaborate with colleagues in both the discovery and development organizations, including scientists in therapeutic area biology, biomolecule formulation and development, ADME, Toxicology, PK/PD, Statistics, Computational Sciences, clinical development, and more. Our team is looking for a motivated scientific leader with protein engineering expertise to join us and to make a difference delivering impactful outcomes for patients and the communities we serve! The successful candidate will lead efforts to discover, design, and engineer protein therapeutics for targeted biological function, potency, time action, stability, developability, and low immunogenicity. Additionally, there will be opportunities to engineer proteins and/or antibodies for targeted delivery of bioconjugates or nucleic acids to cells.

The ideal candidate is a highly motivated teammate, with a passion for goal-oriented scientific research, with industry and supervisory experience and external influence in protein engineering. We need a strong leader with sound practical knowledge of molecular biology, structural biology, biological chemistry, immunology, and cell biology. We invite you to join the Lilly Team today!

Responsibilities:

  • Discover and engineer first- or best-in-class biotherapeutics by integrating biology and a deep understanding of molecular properties

  • Innovate to improve core technologies (antibody and protein engineering) and build the next wave of innovation (new platform technologies).

  • Employ cutting-edge computational bioscience and immunogenicity assessment capabilities to accelerate discovery and engineering of biotherapeutics with optimal developability, PK/PD, and safety profile.

  • Supervise and mentor Scientists and Research Associates.

  • Critically analyze, interpret, and report experimental results. Draw appropriate conclusions and identify new strategies to design and optimize novel biotherapeutics.

  • Coordinate and present data to support decisions in cross-functional teams.

  • Prepare, review, and sign off on technical documents and reports.

  • Review the literature, attend meetings and conferences, and maintain an updated knowledge in the field.

  • Contribute to the preparation of scientific products, such as original research publications and presentations, writing reports, protocols, and regulatory documents when appropriate.

Basic Qualifications:

Ph.D. in protein biochemistry, biophysics, biological chemistry, structural biology, or related field with >5 years of relevant experience beyond education/postdoctoral training in a pharmaceutical, biotech, or research organization

Additional Skills/Preferences:

  • 10 years experience in biotech or pharmaceutical industry with supervisory and project leadership responsibilities.

  • Passion to use a deep domain knowledge in protein engineering and structural biology to accelerate innovation.

  • Expertise in molecular biology, protein characterization, NGS, lab automation/robotics, protein-protein interactions, SAR, protein conjugation, and protein structure prediction.

  • Extensive experience in engineering and characterization of protein and/or antibody variants as clinical leads.

  • Strong mentor and coach. Dedication to encouraging diverse and inclusive environments.

  • Creative problem-solver who can influence diverse teams to align on strategy.

  • Strong teammate and independent scientist ready to work effectively in a collaborative, fast-paced environment.

  • Ability to foster close relationships with multi-functional colleagues across geographies.

  • Attention to detail and critical thinking. Able to prioritize work and meet targeted timelines.

  • Excellent written and verbal communication skills.

  • Proficiency with Microsoft Office applications as well as advanced scientific software (e.g., Spotfire, JMP, MOE).

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( LillyRecruitingCompliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide valid proof of vaccination to the company.

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people. We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!

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