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Lilly Research Scientist-Cryo EM in San Diego, California

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. For more than 140 years, we have worked purposefully to discover medicines that make life better. These discoveries start in Lilly Research Laboratories, where our scientists work to create new medicines that will help tackle our world’s greatest health challenges. Lilly credits its outstanding employees for its success, and recognizes that the key to ongoing achievement lies in attracting and retaining the best people.

Our Global Structural Biology group at the Lilly Biotechnology Center (LBC) in San Diego is looking to add to our diverse and dynamic team of scientists in the area of Cryo-Electron Microscopy. We are a part of Lilly’s Discovery Chemistry and Research & Technologies Division and responsible for gene-to-structure workflows supporting Lilly’s drug discovery pipeline. Do you have a strong work ethic, scientific curiosity, and track record of cross-functional teamwork? We'd love you to bring your talents to Lilly! Apply today!

Responsibilities for the position

  • Provide cryo-electron microscopy support for a broad range of targets across therapeutic areas, and help drive the expression, purification and cryo-EM structure determination of novel drug targets, particularly membrane proteins

  • Partner closely with other structural biologists, biophysicists, protein biochemists and medicinal chemists to develop integrated approaches and address project specific needs and challenges

  • Collaborate on multidisciplinary teams, presenting scientific data in support of drug discovery projects

  • Support maintenance and basic troubleshooting of in-house microscopy equipment

  • Establish computational workflows for the processing of EM data and refinement of biomolecular structures

  • Provide training to Structural Biology colleagues on EM grid preparation, data collection and analysis

Basic Qualifications

  • PhD in Structural Biology, Biophysics, Biochemistry, Chemistry, or other relevant field with at least 2 years (post degree completion; can include postdoc) relevant experience

  • A strong publication record is highly preferred

Additional Skills/Preferences

  • Compensation commensurate with experience.

  • Proven practical research experience in structure solution of membrane proteins by cryo-Electron Microscopy and membrane protein biochemistry

  • Experienced in Single Particle Analysis and familiarity with the major packages including RELION, cisTEM, and cryoSPARC

  • Flexibility to work in an environment with rapidly changing priorities and time frames, with strong interpersonal, written, and verbal communication and problem-solving skills

  • Experience in the biotech or pharma sector

  • Experience in X-ray crystallography, other biophysical methods (E.g., MS, SPR, MST, X-ray, EM, etc.) is a plus

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide valid proof of vaccination to the company.

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!