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Lilly Research Scientist-Medicinal Chemistry in San Diego, California

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Do you have strong Synthetic Organic or Medicinal Chemistry skills with extensive working knowledge of modern synthetic chemistry methodologies? If you can contribute examples of scientific creativity and ability to ideate independently and in teams solving problems through hypothesis-based experimental design, analysis and integration of complex data sets and mechanism insight, apply today!

The Discovery Chemistry & Technologies organization within Lilly Research Laboratories continues to grow! We seek hardworking scientists to join our Medicinal Chemistry group to make an immediate impact. We're looking for scientists with a strong attention to detail, trouble-shooting skills, a high level of learning agility, the willingness to work across teams. We are an innovative and dynamic group looking to enhance our diverse team and capabilities in drug discovery. We are committed to continually improving our abilities to make life better for patients around the globe. Consider joining our growing team!

We are looking for someone who can:

  • Keep safety as the top priority, striving to maintain a strong safety culture.

  • Formulate hypotheses, and design and synthesize novel small molecules to engage disease modifying targets

  • Demonstrate state-of-the-art structure-based drug design technologies and partner with colleagues in computational chemistry and structural biology to characterize protein-ligand interactions and gain insights supporting de-novo molecular design.

  • Optimize lead compounds to improve potency, selectivity, physicochemical properties and ADMET to meet the target product profiles required to invent high-quality medicines.

  • Deliver high laboratory synthetic efficiency to direct fast-paced SAR iterations through proposal and execution of synthetic routes.

  • Ability to effectively partner and use external CRO resources to implement design ideas and enhance ability to test and form hypotheses.

  • Collaborate with colleagues specialized in high-throughput automated synthesis, route optimization and scale-up.

  • Proactively partner cross-functionally to address specific program needs, increase your overall organization acuity and provide Medicinal Chemistry perspectives.

If working for a company where you feel valued and heard is important, apply today and help us improve the lives of patients around the world.

Basic Qualifications:

  • PhD in Organic or Medicinal Chemistry or related field (or MS in Organic or Medicinal Chemistry or related field with 5+ years demonstrated experience) in supporting drug discovery at the molecular design stage (such as small molecules, oral peptides, and/or RNA Therapeutics).

  • A record of scientific contributions including peer reviewed publications, presentations, and/or patents

Preferred Knowledge, Skills, Abilities, Experiences:

  • Familiarity in pharmaceutical, biotechnology, or academic environments, with knowledge of the following domains of molecule design will be highly valued:

  • Lead optimization to improve properties of compounds, optimize in vitro and in vivo potency, selectivity, and ADMET properties.

  • Contemporary understanding of ligand binding efficiency, energetics, and how to optimize.

  • Demonstrable exposure to new modalities (eg. targeted protein degradations, siRNA, ADCs, oral peptides, etc.) or related discovery chemistry technologies.

  • Biophysical techniques such as X-ray protein structure, SPR, ASMS.

  • Automated Synthesis.

  • Awareness of scientific informatics and data visualization tools (e.g. TIBCO Spotfire, KNIME) to undertake computationally enabled multi-property optimization approaches.

  • Excellent English language oral and written communication skills, ability to engage highly effectively as team player in a multidisciplinary and global environment.

  • Track record of influencing and/or leading projects and initiatives, coordinating multiple scientific activities and team members.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company. If you would like to request an accommodation for medical or religious reasons, you may do so at

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!