Lilly Research Scientist/Sr. Research Scientist-Computational/Structural Biologist in San Diego, California
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
It is an exciting time to join Lilly. The Lilly Biotechnology Discovery Research center at San Diego is growing in key areas including computational biology. Our research focuses on discovering innovative biotherapeutic medicines for unmet patient’s needs, by applying cutting-edge antibody discovery and protein engineering technologies.
The computational biology group covers broadly computational and structural biology, physics-based computation, bioinformatics, and data science. We apply comprehensive computational technologies to accelerate biotechnology research and development. We aim to build an integrated artificial intelligence system to push the boundary of innovation to create better medicines. We work closely with colleagues from discovery and protein engineering, formulation and developability, as well as various therapeutic areas. Our team is looking for a motivated scientist with structural and computational biology expertise to join us and to make a difference for patients and the communities we serve!
Do you have a passion to use a deep understanding of physics, chemistry, and predictive modeling to accelerate innovation? As an outstanding structural/computational biologist and collaborator this scientist will make an impact on our portfolio, with the unique opportunity to help drive discovery projects from inception to early development. Specifically, you will
Develop and establish structure-based computational methods and technical framework to advance discovery and development of wide array of therapeutic modalities including antibody, conjugates, peptide, and fusion proteins
Identify and execute independent structural and computational strategies to accelerate project delivery, as well as to facilitate core platforms
Provide structural biology insights to drive protein design for drug-like properties, or for preferred functionalities
Effectively collaborate with cross-functional project teams; identify key needs and apply computational approaches accordingly
Maintain strong engagement with external professionals and outside vendors
Mentor and develop junior scientists
Ph.D. in structural biology, structural bioinformatics, or related field; postdoc experience preferred
3 or more years of relevant experience beyond education/postdoctoral training in a pharmaceutical, biotech, or research organization
Deep domain expertise on protein structure prediction, computational analysis on protein properties, protein-protein interaction, and/or protein-ligand docking and screening
Proficient with state-of-the-art computational tools, such as MOE/CCG, Schrodinger, Discovery Studio/Biovia
Effective written and oral communication skills
Experience with molecular dynamics simulation, coarse-grained simulation
Protein chemistry or protein engineering experience is a plus
Creative problem solver and be able to influence team in positive direction
Strong teammate and willingness to work effectively in a collaborative, fast-paced, multi-tasking environment
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At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people. We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!