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Lilly Research Scientist/Sr. Research Scientist-Structural Biology-Computation in San Diego, California

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

It is an exciting time to join Lilly. The Lilly Biotechnology Discovery Research center at San Diego is growing in key areas including computational biology. Our research focuses on discovering innovative biotherapeutic medicines for unmet patient’s needs, by applying ground breaking antibody discovery and protein engineering technologies.

Here in the computational bioscience group we apply comprehensive computational technologies to accelerate biotechnology research and development. We aim to build an integrated artificial intelligence system to push the boundary of innovation to create better medicines. We work closely with colleagues from discovery and protein engineering, formulation and development, as well as various therapeutic areas. Our team is looking for a motivated scientist with structural and computational biology expertise to join us and to make a difference for patients and the communities we serve!

As an outstanding structural/computational biologist and collaborator this scientist will make an impact on our portfolio, with the unique opportunity to help drive discovery projects from inception to early development. Specifically, you will

  • Develop and establish structure-based computational methods and technical framework to advance discovery and development of wide array of therapeutic modalities including antibody, conjugates, peptide, and fusion proteins

  • Identify and execute independent structural and computational strategies to accelerate project delivery, as well as to facilitate core platforms

  • Provide structural biology insights to drive protein design for drug-like properties, immunogen or for preferred functionalities

  • Effectively collaborate with cross-functional project teams; identify key needs and apply computational approaches accordingly

  • Maintain strong engagement with external professionals and outside vendors

  • Mentor and develop junior scientists

Basic Requirements:

  • Ph.D. in structural biology, structural bioinformatics, or related field; postdoc and/or industry experience preferred

Additional Preferences:

  • 3 or more years of relevant experience beyond education/postdoctoral training in a pharmaceutical, biotech, or research organization

  • Deep domain expertise on protein structure prediction, computational analysis on protein properties, protein-protein interaction, and/or protein-ligand docking and screening

  • Proficient with powerful computational tools, such as MOE/CCG, Schrodinger, Discovery Studio/Biovia

  • Effective written and oral communication skills

  • Experience with molecular dynamics simulation, coarse-grained simulation

  • Protein chemistry or protein engineering experience is a plus

  • Creative problem solver and be able to influence team in positive direction

  • Strong teammate and willingness to work effectively in a collaborative, fast-paced, multi-tasking environment

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company. If you would like to request an accommodation for medical or religious reasons, you may do so at

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!