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Loxo@Lilly Scientific Lead, Enzymology in San Diego, California

About Loxo@Lilly:

Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.

The Enzymology Scientist or Sr. Scientist will be responsible for developing and performing enzyme and binding assays to support drug discovery and development in a team environment. The scientist fulfilling this position will be responsible for characterizing the effects of small molecules on specific protein targets and will provide enzymology expertise to the project teams. A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.

Roles and Responsibilities of the Position:

  • Design, develop, and execute enzyme and binding assays in multiple formats

  • Screen small molecule inhibitors in plate-based assays formats to drive internal structure-based drug design

  • Operate, implement, and troubleshoot laboratory automation

  • Actively engage in advancing small molecule drug discovery oncology programs

  • Perform comprehensive data analysis

  • Communicate experimental findings to team members

  • Operate, implement, and troubleshoot laboratory automation

  • Actively engaged in advancing drug discovery programs

  • This is a “hands-on” laboratory, based position

Required Qualifications and Preferred Background:

  • BS/MS/PhD in biochemistry, biophysics, or related fields is required. Level is commensurate on degree and years of experience.

  • Required experience: BS/MS with 5+ years industry or academic research experience OR PhD with 2+ years’ experience in industry or academic/research setting . Level commensurate with education and experience.

  • The successful candidate is expected to have expertise in biochemistry, enzymology, and assay development

  • Experience with general biochemical and kinetic-based assay technologies (e.g. TR-FRET, AlphaLISA® FP, Luminescence)

  • Experience with laboratory instrumentation and automation for medium to high-throughput screening

  • Excellent oral and written communication skills including experimental documentation

  • Works well with team members across functional areas

  • Ability to multi-task and shift priorities rapidly to meet tight deadlines

  • Highly organized with exceptional attention to detail.

  • Good and thoughtful listener

  • Enthusiastic, self-motivated and a continuous learner

  • Proficient in Microsoft Office suite and applications

Loxo@Lilly currently anticipates that the base salary for the Principal Scientist level position could range from between $90,000 to $132,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands / Travel:

The physical demands of this job are consistent with a lab.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.