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Loxo@Lilly Principal Scientist, Biophysical Chemistry in South San Francisco, California

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Principal Scientist, Biophysical Chemistry, Large Molecule Discovery of Loxo@Lilly will play a critical role in characterization of antibody hits, stability/developability assessments and lead optimization.

The role will be responsible for screening and characterization of antibodies and antibody-drug conjugate candidate molecules generated by discovery and bioconjugation, and subject candidate molecules to developability assessment and optimization, using various biophysical platforms. This individual contributor within the Biophysical Chemistry group will require a clear understanding of the strategies laid out by the Loxo Large Molecule Discovery team.

Roles and Responsibilities of the Position:

  • Participate in building a team with scientists and associates (at various levels) to be part of the larger Protein Engineering Group of the Large Molecule Discovery team at Loxo@Lilly

  • Work with other Protein Engineering team members to screen, characterize and investigate, using analytical and biophysical platforms and methodologies, large biologicals comprised of antibodies, antibody conjugates, multi specifics and other modalities, created for treatment of several oncological indications

  • Hands-on role to design, independently execute key experiments for biophysical characterization of these large molecules from early discovery to early development stage that includes accelerated stability and developability assessments

  • Experience in lead optimization would a plus

  • Interact and collaborate with other teams across the company to provide biophysical solutions; analyze, collate, and disseminate data to teams in a timely manner

  • Participate and present periodic updates and reports to senior management to significantly influence strategic research decisions and operations

  • Liaise with CROs and vendors for contract work and evaluations

  • Participate in long-term strategies for creation of innovative solutions and intellectual property for securing FTO for Loxo

Required Qualifications and Preferred Background:

  • Ph.D. in life or analytical sciences or equivalent fields with at least 5 years of relevant job experience in the biopharma industry with good understanding of drug development process of therapeutic antibodies, antibody conjugates, bi and multi-specific molecules and other modalities

  • Extensive demonstrated expertise in characterization of biomolecular interactions using various industry standard SPR, BLI, and other relevant platforms for characterization of high/low affinities, concentrations, cross-blocking, activity, binding models, heterogeneities, and other product defining characteristics

  • Experience in laboratory automation for liquid handling and screening

  • Experience with spectroscopic techniques for characterization of biomolecules (e.g. UV/Fluorescence)

  • Knowledge of biophysical techniques and platforms for characterization of physical, chemical, and conformational stabilities of biologics. Experience with cIEF, CE-SDS, or DSF or SEC-MALS would be a plus

  • Knowledge of antibody design and engineering approaches (e.g. modeling, cloning & expression) for optimization of CMC properties will be a plus

  • Hands-on experience with vendor provided software for biosensor data analysis and visualization. Experience with additional software tools such as GraphpadPrism, R, Matlab, Spotfire etc would be a plus

  • Prior experience participating in team efforts for antibody lead panel generation, lead optimization and IND enabling studies

  • Supervision of a team by providing clear direction, setting expectations, and mentoring young scientists

  • Must have a can-do attitude to take on challenging projects and innovative ideas to accomplish in a collaborative matrixed organization

  • Excellent communication skills and with strong organizational abilities

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/ Travel:

Travel: TBD

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab setting

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.