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Loxo@Lilly Principal/Senior Principal Scientist, Mass Spec, Large Molecule Discovery in South San Francisco, California

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Principal/Senior Principal Scientist, Mass Spec, Large Molecule Discovery will play an important role in the discovery and development of transformative therapeutics in the Loxo@Lilly Large Molecule Discovery team. The role requires a clear understanding of Large Molecule Discovery strategy. This role will potentially lead a team that will address challenges in characterization of antibodies, reagent proteins and ADCs with mass-spectrometry. This includes conducting and overseeing experiments for protein/ antibody peptide mapping, intact mass analysis, post-translational modification (PTM) analysis, ADC characterization, developability assessment, and pre-clinical in-vivo/pharmacokinetic studies utilizing bioanalytical techniques, mass-spectrometry, and other analytical characterization.

Roles and Responsibilities of the Position:

  • Lead a team that will specialize in characterization of therapeutic proteins that include ADCs, bispecific and other format antibodies, with mass-spectrometry and analytical techniques

  • Responsible for developing strategies that include identification of above listed therapeutic proteins and protein reagents by peptide mapping, intact mass analysis, and post-translational modification (PTM) analysis

  • This role will be tasked with ADC characterization, and developability assessment, and pre-clinical in-vivo/pharmacokinetic studies utilizing bioanalytical techniques

  • Present data at meetings that may include representatives from other departments and/or outside parties and participates in brainstorming and troubleshooting within team, offering, and implementing solutions to problems.

  • Participate in designing, overseeing, and executing key experiments for analytical and mass-spectrometry based characterization of these large molecules from early discovery to early development stage.

  • Interact and collaborate with other teams across the company to provide analytical and mass-spec solutions; analyze, collate, and disseminate data to teams in a timely manner

  • Work cross-functionally as part of internal multi-disciplinary teams, as well as working with external partners and CROs.

Required Qualifications and Background:

  • PhD degree in Chemistry or Biological Science with 6 years’ experience at the Principal Scientist level and 8+ years at the Senior Principal Scientist level or MS/BSc degree in Life or analytical sciences or equivalent fields with at least 12 years of relevant job experience in the biopharma industry with good understanding of drug development process with emphasis on antibody-drug conjugates.

  • Experienced in setting up and maintaining mass-spectrometry and analytical research lab.

  • Demonstrated proven expertise in protein mass-spectrometry for antibodies including LC-MS intact protein analysis, peptide mapping, conjugate analysis, PTMs, de-novo sequencing, and chemical modifications

  • Experienced in small molecule and protein mass-spectrometry of antibody drug-conjugates (ADC) for characterization of conjugation site analysis, positional isomers, free drug, drug stability, and metabolite analysis

  • Experienced in setting up studies for assessment of antibodies and ADCs for developability/CMC and assist in writing of technical reports, SOPs, and regulatory documents for IND

  • Prior experience in participation of team efforts for antibody lead panel generation, lead optimization, and IND enabling studies

  • Demonstrated can-do attitude and brings innovative ideas in challenging projects set up in a collaborative, cross-functional organization

  • Excellent communication skills and with strong organizational abilities

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and the Senior Principal Scientist position level could range from between $118,700 to $174,137 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands/ Travel:

The physical demands of this job are consistent with laboratory bench setting.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

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