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Loxo@Lilly Scientist, Biophysical Chemistry (Contract) in South San Francisco, California

About Loxo@Lilly:

Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.

The Contract Scientist, Biophysical Chemistry will play a pivotal role in performing biophysical analysis of proteins and protein/protein interactions within the Protein Science & Engineering - Biophysical Chemistry group. The scientist in this role will frequently interact with the Biophysical Chemistry and Bioconjugation team leaders and other scientists in a dynamic, team-oriented environment.

The role will be responsible for maintaining lab instrumentation, ordering and preparing reagents, and performing screening and characterization of antibodies and antibody-drug conjugate (ADC) candidate molecules using various biophysical platforms.

Roles and Responsibilities of the Position:

  • Using surface plasmon resonance (SPR) and Biolayer Interferometry (BLI) to characterize the kinetics and affinity of antibody/antigen interactions

  • Using SPR and/or BLI for epitope binning and receptor/ligand blocking studies

  • Characterizing protein stability, purity and quality using a variety of techniques, such as dynamic light scattering (DLS), static light scattering (SLS), capillary isoelectric focusing (cIEF), size exclusion chromatography (SEC), ion exchange chromatography (IEX), CE-SDS, and SDS-PAGE.

  • Clearly documenting experiments and results in electronic lab notebook entries

Required Qualifications and Preferred Background:

  • A BS or MS with 0-3+ years relevant work experience. Level commensurate with education and experience.

  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.

  • Highly organized and detail oriented with excellent analytical, documentation, and multi-tasking skills.

  • Previous experience with therapeutic antibodies, antibody conjugates, bi and multi-specific molecules, and other modalities is a plus

Physical Demands/ Travel:

The physical demands of this job are consistent with laboratory bench setting.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.