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Loxo@Lilly Scientist, Cancer Biology in South San Francisco, California

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

With a strong background in cancer biology, the Scientist, Cancer Biology will support lab-based research projects associated with Loxo@Lilly’s discovery and development programs. This entails independently planning and executing experiments focused on developing a deep understanding of target biology and drug mechanisms of action. The successful candidate will achieve these objectives by prioritizing scientific rigor, by exhibiting a “can-do” approach to solving complex challenges, and by effectively collaborating with Loxo@Lilly discovery and development team members.

Roles and Responsibilities of the Position:

  • Drive and execute in vitro and in vivo studies to investigate mechanisms of cancer cell growth and survival in support of the discovery and development of new cancer therapeutics

  • Establish and perform state-of-the-art cell-based and biochemical assays

  • Design and execute cross-assay validation studies

  • Identify and evaluate new technologies to advance drug discovery and development

  • Analyze and interpret data, with ability to troubleshoot assays

  • Organize and coordinate multiple projects in parallel

  • Identify, evaluate, and manage vendors for outsourced services and studies

  • Prepare and present scientific results at congresses and in peer-reviewed journals

Required Qualifications and Preferred Background:

  • BS, MS, or PhD in biology, molecular biology, cell biology, biochemistry or related discipline. Minimum of 10 years for BS, >5 years for MS and >0-3 years for PhD, either in industry or academic environment

  • Proven track record in design and development of robust assays to study protein expression, protein turnover and protein-protein and protein-small molecule interactions (e.g. MSD, HTRF, AlphaLISA, flow cytometry, co-IP etc.)

  • Extensive experience with aseptic mammalian cell culture and familiarity with solid tumor and/or hematologic cell lines is preferred

  • Demonstrated ability to engineer knock-in & knockout cell lines with CRISPR and/or other technologies

  • Experience working with in vivo mouse models including tissue/blood collection, processing, and analysis

  • Self-organized, detail-oriented, self-directed, highly motivated with strong critical thinking and analytical skills

  • Willingness to work collaboratively and incorporate diverse perspectives into decision-making

  • Demonstrated ability to work successfully in a nimble, fast-paced, matrixed environment

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist position level could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands/ Travel:

The physical demands of this job are consistent with laboratory setting.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.