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Loxo@Lilly Scientist/Senior Scientist, Antibody Discovery, In-Vitro Characterization in South San Francisco, California

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Scientist/Senior Scientist, Antibody Discovery will be responsible for executing antibody binding and functional screens to identify hit sequences from internal and external antibody discovery campaigns. This individual will generate critical in vitro characterization data and reagents to rank order antibody sequences by affinity, in vitro potency, and developability for various Large Molecule Discovery programs. Working closely with other internal teams, the Scientist/Sr Scientist will also support collaborative activities related to lead identification and optimization.

Roles and Responsibilities of the Position:

  • Perform high-throughput antibody binding screens by ELISA and multi-plex flow cytometry to identify hits

  • Develop, optimize, and perform in vitro potency assays to deliver key data for selecting lead panel of antibodies, including bispecific antibodies and antibody drug conjugates

  • Perform tissue cultures to expand and maintain mammalian cell lines (CHO, HEK293, and established cancer cell lines) and primary immune cells for antibody/protein expression and in vitro assays

  • Work collaboratively with Large Molecule Discovery Biologics functional teams to ensure materials and results are delivered on time

  • Demonstrate collection and thorough analysis of data, and update Electronic Notebook records

Required Qualifications and Preferred Background:

  • MS in Biology, Biochemistry, Biomedical Engineering, or related field with minimum of 3+ years of industry experience, or BS with 5+ years of industry experience in biologics drug discovery for Scientist; 7+ years of industry experience for Senior Scientist

  • Must have in tissue cultures experience using mammalian cell lines and primary immune cells using aseptic laboratory techniques

  • Experience in operating and maintaining flow cytometers, plate readers, and liquid handlers, as well as software for data analysis and visualization (Microsoft Office and GraphPad Prism)

  • Highly motivated, fast learner with strong organization skills

  • Demonstrate experience in working collaboratively across various scientific disciplines to meet end goals of business

  • Demonstrate ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines

  • Excellent written and verbal communication skills

  • Strong interpersonal skills

Preferred Qualifications:

  • Single B cell cloning or hybridoma based antibody discovery experience

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist position level could range from between $78,000 to $114,498 and the base salary at the Sr. Scientist level could range between $89,750 and $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands/ Travel: TBD <5%

The physical demands of this job are consistent with working in a lab.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.