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Loxo@Lilly Scientist/Senior Scientist, Target Discovery in South San Francisco, California

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Scientist/Senior Scientist, Target Discovery will be part of the Loxo@Lilly’s Discovery group identifying the next generation of molecular targets for cancer therapeutics. The Scientist/Senior Scientist, Target Discovery will be responsible for creating and executing strategies toward discovery and early validation of oncology targets through close collaboration with other discovery and translational functions. The Scientist/Senior Scientist, Target Discovery will have a strong understanding of oncogenic pathways and experience in designing experiments to evaluate molecular interactions and pathways. The Scientist/Senior Scientist, Discovery Biology will be part of a multi-disciplinary effort focused on high-quality, truth-seeking science to bring forward innovative cancer drug therapy.

Roles and Responsibilities of the Position:

  • Create, develop and validate quantitative mammalian cellular assays to credential novel targets

  • Establish robust high-throughput screening assays

  • Design and manage in vivo pre-clinical studies

  • Conceive and lead collaborative projects on biomarker-driven programs

  • Evaluate emerging technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way

  • Collaborate with colleagues throughout the company to ensure assays meet the program needs and results are appropriately interpreted

  • Participate and thrive in an interactive, team-oriented culture

  • Directly manage and mentor lab-based staff

Required Qualifications and Preferred Background:

  • PhD in Molecular/Cellular Biology or Biochemistry, or related field

  • Minimum of 1-3+ years of postdoctoral and/or hand-on research experience, preferability in biotech/pharma setting

  • Experience in relevant areas of cancer and molecular biology

  • Outstanding communication, writing, and presentation skills is a must

Additional Preferred Qualifications:

  • Experience with cell engineering such as knock-in and knockdown cell lines with CRISPR and/or other technologies

  • Experience with flow cytometry and general molecular biological techniques including q-PCR, signaling experiments, assays for protein-protein interactions and Western Blot etc.

  • Experience in designing and handling in vivo animal studies

  • Experience in building models (cell line, organoid or PDX) from patient samples and using them to test drug activities

  • Experience working with external CROs

  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels and problem solving skills

  • Ability to summarize complex experiment and results for non-specialists

  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist position level could range from between $78,000 to $114,498 and that the base salary for the Senior Scientist position level could range from between $89,750 to $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands / Travel

The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab/bench environment.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.