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Loxo@Lilly Senior Associate Scientist/Scientist, Target Discovery (in-vivo) in South San Francisco, California

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a highly motivated and experienced individual to join a dynamic and fast-paced Target Discovery Biology team. Under the guidance of a principal or senior principal scientist. The successful candidate will apply state-of-the-art technologies to design and execute in vivo studies as well as ex vivo experiments to identify and validate novel druggable targets.

The ideal candidate is a team player familiar with routine molecular, cellular biology and in vivo techniques and has demonstrated organizational skills. He/She will learn various cutting-edge techniques and thrive in a team-oriented environment with career growth opportunity.

Roles and Responsibilities of the Position:

  • Design vectors to generate transgenic mouse models to study novel targets

  • Maintain and establish various mammalian cell lines used to credential novel targets

  • Design, plan and/or execute in vivo experiments by using mouse models to evaluate the outcome of tumor progression in mouse models for different cancers

  • Perform cellular and biochemical assays to evaluate the outcome of various genetic or chemical perturbations.

  • Mouse colony management

  • Analyze, interpret, and present the data to the team and/or organization

  • Troubleshoot experiments in a timely manner

  • Learn and apply new techniques to support ongoing efforts

  • Actively participate in group discussions and collaborate with colleagues throughout the organization.

  • Contribute to a safe and efficient workplace

Required Qualifications and Preferred Background:

  • BS, MS, or PhD in biology, cancer, molecular biology, cell biology, biochemistry, or related discipline, with 3+ years lab-based experience

  • Mouse experience is highly desired but not required

  • Expertise in routine molecular and cellular techniques

  • Experience in gene editing (CRISPR, TALEN, etc.) and/or high-throughput screening is a plus.

  • Excellent collaborative and interpersonal skills

  • Highly organized, detail-oriented, self-motivated and strong documentation skills

  • Outstanding communication, writing, and presentation skills are a must

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Associate Scientist level position could range from between $67,850 to $99,563 and the that the base salary for the Scientist level position could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands:

The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a laboratory/bench environment.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.